Jill Kreiling

About

Jill Kreiling is a Professor of Molecular Biology, Cell Biology, and Biochemistry with a research focus on aging and chromatin biology. She has held positions at Brown University since 2006, including Associate Professor (Research) at the Brown University School of Medicine and Associate Director of the Brown Center on the Biology of Aging. Her work investigates the molecular mechanisms underlying aging, particularly the regulation of heterochromatin formation and the activity of transposable elements in aging mammalian tissues. Kreiling's research aims to identify biomarkers and understand the epigenetic changes associated with aging, with a specific interest in neural stem cell decline, transposable element activity, and heterochromatin dynamics. She has contributed to advancing knowledge in these areas through her extensive publication record and leadership in funded projects related to aging, stem cells, and epigenetics.

Research topics

• Biology
• Genetics
• Bioinformatics
• Internal medicine
• Medicine
• Computational biology
• Pharmacology
• Neuroscience
• Evolutionary biology
• Psychology

Selected publications

• Loss of epigenetic information as a cause of mammalian aging

  Cell · 2023 · 603 citations

  PublisherOA PDFDOI

• The role of retrotransposable elements in ageing and age-associated diseases

  Nature · 2021 · 427 citations

  PublisherOA PDFDOI

• Sex‐specific aging in animals: Perspective and future directions

  Aging Cell · 2022-01-23 · 96 citations

  reviewOpen access

  Sex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age-associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer-lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, w…

  PublisherOA PDFDOI

• Timing and cell specificity of senescence drives postnatal lung development and injury

  Nature Communications · 2023-01-17 · 44 citations

  articleOpen access

  Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence contributes to lung development or injury in early life remains unclear. Here, we show that lung senescence occurred at birth and decreased throughout the saccular stage in mice. Reducing senescent cells at this stage disrupted lung development. In mice (<12 h old) exposed to hyperoxia during the saccular stage followed by air recovery until adultho…

  PublisherOA PDFDOI

• Loss of epigenetic information as a cause of mammalian aging

  Cell · 2024-02-01 · 38 citations

  erratumOpen access
  PublisherOA PDFDOI

Recent grants

• Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders

  NIH · $3.9M · 2022–2027

• NIH Grant K01AG039410

  NIH · $582k · 2017

• Regulation of Neural Stem Cell Quiescence by FOXO3 During Aging

  NIH · $20.4M · 2020–2024

Frequent coauthors

• John M. Sedivy

  Brown University

  52 shared

• Robbert Créton

  Providence College

  45 shared

• Sayali V. Gore

  Providence College

  25 shared

• Thaís Del Rosario Hernández

  Brown University

  25 shared

• Bianca Kun

  Brown University

  22 shared

• Nicola Neretti

  Providence College

  20 shared

• Steven W. Criscione

  AstraZeneca (United States)

  20 shared

• Abigail L. Peterson

  Providence College

  20 shared

Labs

• Kreiling, JillPI

Education

• Ph.D.

  Brown University School of Medicine

• M.D.

  Brown University School of Medicine

• B.A.

  Brown University

Similar researchers at Brown University

• Karen Furieh-148
• Rena Wingh-146
• Lawrence Priceh-132