Karen Furie

About

Karen L. Furie is the Samuel I. Kennison, M.D., and Bertha S. Kennison Professor of Clinical Neuroscience, Professor of Neurology, and Chair of Neurology at Brown University. She received her undergraduate degree in English and American Literature from Brown University in 1987, earned her MD from Brown University School of Medicine in 1990, and completed a Masters in Public Health at Harvard University in 1996. Her medical training includes an internship at Miriam Hospital, a Neurology Residency, and a Fellowship in Cerebrovascular Disease at Rhode Island Hospital. Dr. Furie's career has been dedicated to clinical and translational stroke research, with a focus on stroke prevention, cerebrovascular disease, and neurology. She has developed collaborative multispecialty initiatives and has been supported continuously by NIH and foundation grants. Her research has defined optimal antithrombotic therapy for stroke prevention, clarified the role of high-dose vitamins in hyperhomocysteinemia treatment, and provided insights into the pathophysiology of ischemic stroke. She has led multiple significant research projects, including the NINDS P50 Partners SPOTRIAS and the Harvard Bugher Center for Stroke Prevention and Genetics Research. Her current research focuses on the interaction between oxidative stress and matrix metalloproteinases to better understand injury mechanisms in acute stroke and identify potential intervention targets. She is also involved in examining dietary…

Research topics

• Medicine
• Internal medicine
• Cardiology
• Surgery
• Family medicine
• Radiology
• Intensive care medicine
• Medical emergency

Selected publications

• Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy

  JAMA · 2024 · 177 citations

  Importance: Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It is unknown whether anticoagulation, which has proven benefit in atrial fibrillation, prevents stroke in patients with atrial cardiopathy and no atrial fibrillation. Objective: To compare anticoagulation vs antiplatelet therapy for secondary stroke prevention in patients with cryptogenic stroke and evidence of atrial cardiopathy. Design, Setting, and Participants: Multicenter, do…

  DOI

• Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study

  Journal of Neurology Neurosurgery & Psychiatry · 2021 · 66 citations

  BACKGROUND AND PURPOSE: A subset of ischaemic stroke patients with atrial fibrillation (AF) have ischaemic stroke despite anticoagulation. We sought to determine the association between prestroke anticoagulant therapy and recurrent ischaemic events and symptomatic intracranial haemorrhage (sICH). METHODS: We included consecutive patients with acute ischaemic stroke and AF from the Initiation of Anticoagulation after Cardioembolic stroke (IAC) study from eight comprehensive stroke centres in the…

  PublisherOA PDFDOI

• Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke

  Journal of Neuroimaging · 2020 · 39 citations

  BACKGROUND AND PURPOSE: In patients with symptomatic vertebrobasilar intracranial atherosclerotic disease (ICAD), impaired distal flow predicts recurrent stroke, but limited data exist on the association between perfusion status and recurrent stroke in anterior circulation ICAD. METHODS: This is a retrospective study of patients hospitalized for symptomatic ICAD with 50-99% stenosis of the intracranial carotid or middle cerebral artery. The primary outcome is recurrent symptomatic ischemic strok…

  DOI

• Carotid Revascularization Versus Medical Management for Ischemic Stroke with Ipsilateral Carotid Web: A Systematic Review and Meta‐Analysis

  Annals of Neurology · 2025-06-12 · 11 citations

  review

  Objectives Carotid artery web is an underrecognized cause of ischemic stroke and is associated with a high risk of recurrent events. It is uncertain whether medical management or carotid revascularization is beneficial for patients with ischemic stroke and ipsilateral carotid web. In the absence of large randomized clinical trials and observational studies, we performed a systematic review and meta‐analysis comparing medical management and carotid revascularization in this population. Methods Th…

  PublisherDOI

• Intravenous Thrombolysis in Cervical Artery Dissection–Related Stroke: A Nationwide Study

  Journal of the American Heart Association · 2025-02-19 · 5 citations

  articleOpen access

  Background Although intravenous thrombolysis (IVT) is safe and effective in populations with general stroke, its impact on cervical artery dissection–related acute ischemic stroke (CeAD‐AIS) remains unclear. This retrospective study used the National Inpatient Sample to compare outcomes in patients with CeAD‐AIS treated with and without IVT. Methods We included adult patients with concurrent CeAD and AIS diagnoses ( International Classification of Diseases, Tenth Revision [ ICD‐10 ], codes) hosp…

  PublisherDOI

Recent grants

• NIH Grant K23NS042720

  NIH · $852k · 2006

• NIH Grant R01HS011392

  NIH · $2.0M · 2008

• NIH Grant P50NS051343

  NIH · $19.8M · 2017

Frequent coauthors

• Shadi Yaghi

  Providence College

  752 shared

• Walter J. Koroshetz

  660 shared

• Michael H. Lev

  479 shared

• Michael Reznik

  University of Pittsburgh Medical Center

  456 shared

• Brian Mac Grory

  Duke University

  454 shared

• Natalia S. Rost

  Massachusetts General Hospital

  425 shared

• Jonathan Rosand

  Massachusetts General Hospital

  424 shared

• Mahesh Jayaraman

  Brown University

  406 shared

Education

• B.A., English and American Literature

  Brown University

  1987

• M.D.

  Brown University School of Medicine

  1990

• M.S., Public Health

  Harvard University School of Public Health

  1996

Similar researchers at Brown University

• Rena Wingh-146
• Lawrence Priceh-132
• Richard Jonesh-126