Nicola Neretti

About

Our research group combines genomics and computational biology to study the biology of aging and age-associated diseases

Research topics

• Biology
• Genetics
• Cell biology
• Medicine
• Immunology
• Computational biology
• Gerontology
• Internal medicine
• Neuroscience

Selected publications

• Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

  Aging Cell · 2021 · 393 citations

  exclusively in the microglial population, resulting in reduced microglial activation and reduced expression of SASP factors. Importantly, both approaches significantly improved cognitive function in aged mice. Our data provide proof-of-concept for senolytic interventions' being a potential therapeutic avenue for alleviating age-associated cognitive impairment.

  DOI

• SenNet recommendations for detecting senescent cells in different tissues

  Nature Reviews Molecular Cell Biology · 2024-06-03 · 320 citations

  reviewOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

• Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

  The EMBO Journal · 2021 · 204 citations

  Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro-inflammatory phenotype, thought to contribute to aging and age-related diseases. Neutrophils have essential roles in inflammatory responses; however, in certain contexts their abundance is associated with a number of age-related diseases, including liver disease. The relationship between neutrophils and cellular senescence is not well understood. Here, we show that telomeres in non-immune cells are highly…

  PublisherOA PDFDOI

• NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

  Nature Aging · 2022 · 122 citations

  PublisherOA PDFDOI

• Spatial mapping of cellular senescence: emerging challenges and opportunities

  Nature Aging · 2023 · 116 citations

  PublisherOA PDFDOI

Recent grants

• BioMedical Big Data Core

  NIH · $45.2M · 2016–2026

• The Role of Somatic Transposition in Age-associated Genomic Instability

  NIH · $2.2M · 2017–2024

• Brown University Training Program in the Molecular Biology of Aging

  NIH · $2.9M · 2012–2027

Frequent coauthors

• John M. Sedivy

  Brown University

  87 shared

• Nathan Intrator

  79 shared

• Stephen L. Helfand

  Brown University

  65 shared

• Steven W. Criscione

  AstraZeneca (United States)

  63 shared

• Yee Voan Teo

  Brown University

  53 shared

• Shane A. Evans

  Teikoku Pharma (United States)

  48 shared

• Marco De Cecco

  Brown University

  36 shared

• Leon N. Cooper

  University of Sydney

  31 shared

Similar researchers at Brown University

• Karen Furieh-148
• Rena Wingh-146
• Lawrence Priceh-132