John Sedivy

About

John M Sedivy is the Hermon C. Bumpus Professor of Biology, Associate Dean, and Director of the Center for the Biology of Aging at Brown University. He joined the Brown faculty in 1996 and is a member of the Department of Molecular Biology, Cell Biology and Biochemistry. Sedivy obtained his PhD from Harvard University in 1985 and trained with Nobel Laureate Philip Sharp at the MIT Center for Cancer Research. His independent research career began at Yale University in 1988. His research focuses on cell cycle regulation and signal transduction, initially on the Myc oncogene and later on replicative senescence, which is cellular aging. His work on these topics has been continuously funded by the National Institutes of Health since 1989. Sedivy's research has expanded into genomics, bioinformatics, and systems biology, with significant contributions to understanding cellular senescence through the development of single-cell assays and the study of telomere-initiated senescence. He has also contributed to epigenetics, chromatin regulation, and aging-related genome changes. Sedivy has authored over 140 original articles and has served on numerous study sections and advisory committees at NIH, the American Cancer Society, and the US Army Breast Cancer Initiative. He has also consulted extensively for biotech companies and maintains an active role in aging research as a founding member and current chair of the CMAD study section at NIH, co-Editor-in-Chief of Aging Cell, and chair of…

Research topics

• Biology
• Genetics
• Chemistry
• Computational biology
• Evolutionary biology
• Biochemistry
• Immunology
• Mathematics
• Cell biology
• Gerontology

Selected publications

• Loss of epigenetic information as a cause of mammalian aging

  Cell · 2023 · 603 citations

  PublisherOA PDFDOI

• The role of retrotransposable elements in ageing and age-associated diseases

  Nature · 2021 · 427 citations

  Senior authorCorresponding
  PublisherOA PDFDOI

• CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

  Nature Metabolism · 2020 · 321 citations

  DOI

• Guidelines for minimal information on cellular senescence experimentation in vivo

  Cell · 2024-08-01 · 262 citations

  reviewOpen access

  Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development of new tools to study senescence in vivo has paved the way for uncovering its physiological and pathological roles and testing senescent cells as a therapeutic target. However, the lack of specific and broadly applicable markers makes it difficult to identify…

  PublisherOA PDFDOI

• NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

  Nature Aging · 2022 · 122 citations

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01AG035328

  NIH · $952k · 2013

• NIH Grant R21AG049608

  NIH · $250k · 2017

• The Role of Somatic Transposition in Age-associated Genomic Instability

  NIH · $2.2M · 2017–2024

Frequent coauthors

• Nicola Neretti

  Providence College

  87 shared

• Wenyi Wei

  Beth Israel Deaconess Medical Center

  58 shared

• Marco De Cecco

  Brown University

  57 shared

• Jill A. Kreiling

  Brown University

  52 shared

• Wendy A. Jobling

  University of Florida

  48 shared

• William C. Hahn

  Dana-Farber Cancer Institute

  38 shared

• Stephen L. Helfand

  Brown University

  33 shared

• Utz Herbig

  Rutgers, The State University of New Jersey

  33 shared

Education

• Ph.D.

  Harvard

  1985

• Other

  MIT Center for Cancer Research

Awards & honors

• Founding member and current chair of the CMAD study section…
• Co-Editor-in-Chief of the journal Aging Cell
• Chair of the 2015 Gordon Research Conference on the Biology…

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