Robbert Creton

About

Robbert Creton is a Professor of Medical Science (Research) and a Professor of Pathology and Laboratory Medicine (Research) at Brown University. He received his B.S. in Biology in 1990 and his Ph.D. in Developmental Biology in 1994 from the University of Utrecht in the Netherlands. His post-doctoral training was in developmental physiology at the Marine Biological Laboratory in Woods Hole, Massachusetts. He was appointed as an investigator at Women & Infants Hospital of Rhode Island before joining Brown University in 2002. His research focuses on brain development and behavior using zebrafish as a model system, with particular interest in understanding mechanisms underlying visual impairment, developmental brain disorders, and neurodegenerative diseases such as Alzheimer’s. He is the director of the Leduc Bioimaging Facility, which provides high-resolution imaging equipment and training for life sciences research. His laboratory has developed automated imaging and behavioral analysis tools that are used to study neural and behavioral responses, including the effects of environmental toxicants and pharmacological agents on zebrafish development and behavior. His work aims to contribute to the understanding of biological mechanisms involved in neurodevelopment and neurodegeneration, and to facilitate the development of treatments for related human disorders.

Research topics

• Internal medicine
• Biology
• Medicine
• Cell biology
• Neuroscience
• Pharmacology
• Bioinformatics
• Psychology
• Genetics

Selected publications

• Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity

  NeuroToxicology · 2015-05-14 · 70 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

• Phenotypic Plasticity Regulates Candida albicans Interactions and Virulence in the Vertebrate Host

  Frontiers in Microbiology · 2016-05-26 · 49 citations

  articleOpen access

  Phenotypic diversity is critical to the lifestyles of many microbial species, enabling rapid responses to changes in environmental conditions. In the human fungal pathogen Candida albicans, cells exhibit heritable switching between two phenotypic states, white and opaque, which yield differences in mating, filamentous growth, and interactions with immune cells in vitro. Here, we address the in vivo virulence properties of the two cell states in a zebrafish model of infection. Multiple attributes…

  PublisherOA PDFDOI

• Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on larval zebrafish behavior

  Neurotoxicology and Teratology · 2015-11-10 · 37 citations

  article
  PublisherDOI

• RNA structure replaces the need for U2AF2 in splicing

  Genome Research · 2015-11-13 · 36 citations

  articleOpen access

  RNA secondary structure plays an integral role in catalytic, ribosomal, small nuclear, micro, and transfer RNAs. Discovering a prevalent role for secondary structure in pre-mRNAs has proven more elusive. By utilizing a variety of computational and biochemical approaches, we present evidence for a class of nuclear introns that relies upon secondary structure for correct splicing. These introns are defined by simple repeat expansions of complementary AC and GT dimers that co-occur at opposite boun…

  PublisherOA PDFDOI

• Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish

  NeuroToxicology · 2015-12-31 · 34 citations

  articleOpen access
  PublisherOA PDFDOI

Recent grants

• Calcium Signaling in the Developing Zebrafish Brain

  NSF · $344k · 2004–2007

• Automated analyses of behavior in response to visual stimuli

  NIH · $1.4M · 2015–2021

• Emerging imaging technologies for automated analyses of calcineurin-dependent brain function

  NIH · $1.3M · 2020–2025

Frequent coauthors

• Ruth M. Colwill

  John Brown University

  52 shared

• Jill A. Kreiling

  Brown University

  45 shared

• Peter J. Mohler

  The Ohio State University

  36 shared

• Andrew L. Miller

  iThemba Laboratory

  36 shared

• E. Karplus

  Science Wares (United States)

  36 shared

• Carole L. Browne

  36 shared

• Robert E. Palazzo

  36 shared

• Thaís Del Rosario Hernández

  Brown University

  33 shared

Education

• B.S., Biology

  University of Utrecht

  1990

• Ph.D., Developmental Biology

  University of Utrecht

  1994

Similar researchers at Brown University

• Karen Furieh-148
• Rena Wingh-146
• Lawrence Priceh-132