Theoklis E Zaoutis

About

Theoklis E Zaoutis, MD, MSCE, PhD, is an Emeritus Professor and Chair of Pediatrics (Infectious Diseases) at the University of Pennsylvania's Perelman School of Medicine. He completed his undergraduate degree in Biology at the State University of New York at Stonybrook in 1985, followed by a Master of Clinical Microbiology at Hahnemann University in 1987. He earned his MD from Jefferson Medical College of Thomas Jefferson University in 1996, and later obtained a Master’s in Clinical Epidemiology and Biostatistics from the University of Pennsylvania School of Medicine in 2005. In 2014, he completed a PhD at the National and Kapodistrian University of Athens School of Medicine. Zaoutis's research focuses on infectious diseases, clinical epidemiology, and biostatistics, with significant contributions to pediatric infectious diseases. His work includes investigations into antimicrobial stewardship, healthcare-associated infections, and the effectiveness of treatments for COVID-19. He has authored numerous publications in these areas, contributing to the advancement of pediatric infectious disease knowledge and clinical practice.

Research topics

• Medicine
• Intensive care medicine
• Immunology
• Pediatrics
• Pathology

Selected publications

• Clinical Practice Guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on Diagnosis and Management of Acute Hematogenous Osteomyelitis in Pediatrics

  Journal of the Pediatric Infectious Diseases Society · 2021 · 264 citations

  This clinical practice guideline for the diagnosis and treatment of acute hematogenous osteomyelitis (AHO) in children was developed by a multidisciplinary panel representing Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA). This guideline is intended for use by healthcare professionals who care for children with AHO, including specialists in pediatric infectious diseases, orthopedics, emergency care physicians, hospitalists, and any clinicians a…

  PublisherDOI

• Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review

  Antimicrobial Resistance and Infection Control · 2020-01-03 · 189 citations

  articleOpen access

  Abstract Background Antibiotics are the most common medicines prescribed to children in hospitals and the community, with a high proportion of potentially inappropriate use. Antibiotic misuse increases the risk of toxicity, raises healthcare costs, and selection of resistance. The primary aim of this systematic review is to summarize the current state of evidence of the implementation and outcomes of pediatric antimicrobial stewardship programs (ASPs) globally. Methods MEDLINE, Embase and Cochra…

  PublisherOA PDFDOI

• Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children

  JAMA Pediatrics · 2022-01-18 · 148 citations

  articleOpen access

  IMPORTANCE: Childhood community-acquired pneumonia (CAP) is usually treated with 10 days of antibiotics. Shorter courses may be effective with fewer adverse effects and decreased potential for antibiotic resistance. OBJECTIVE: To compare a short (5-day) vs standard (10-day) antibiotic treatment strategy for CAP in young children. DESIGN, SETTING, AND PARTICIPANTS: Randomized double-blind placebo-controlled clinical trial in outpatient clinic, urgent care, or emergency settings in 8 US cities. A…

  PublisherOA PDFDOI

• Short-Course Therapy for Urinary Tract Infections in Children

  JAMA Pediatrics · 2023-06-26 · 48 citations

  letterOpen access1st author

  Importance: There is a paucity of pediatric-specific comparative data to guide duration of therapy recommendations in children with urinary tract infection (UTI). Objective: To compare the efficacy of standard-course and short-course therapy for children with UTI. Design, Setting, Participants: The Short Course Therapy for Urinary Tract Infections (SCOUT) randomized clinical noninferiority trial took place at outpatient clinics and emergency departments at 2 children's hospitals from May 2012, t…

  PublisherOA PDFDOI

• Policy Statement: Antibiotic Stewardship in Pediatrics

  Journal of the Pediatric Infectious Diseases Society · 2021-01-05 · 44 citations

  article

  Antibiotic overuse contributes to antibiotic resistance, which is a threat to public health. Antibiotic stewardship is a practice dedicated to prescribing antibiotics only when necessary and, when antibiotics are considered necessary, promoting the use of the appropriate agent(s), dose, duration, and route of therapy to optimize clinical outcomes while minimizing the unintended consequences of antibiotic use. Because there are differences in common infectious conditions, drug-specific considerat…

  PublisherDOI

Recent grants

• NIH Grant K23AI062975

  NIH · $666k · 2010

• Multi-center studies to improve diagnosis and treatment of pediatric candidiasis

  NIH · $2.9M · 2013–2019

Frequent coauthors

• Susan Coffin

  Children's Hospital of Philadelphia

  231 shared

• Jeffrey S. Gerber

  Children's Hospital of Philadelphia

  163 shared

• Brian T. Fisher

  University of Pennsylvania

  160 shared

• Priya A. Prasad

  University of California, San Francisco

  96 shared

• William J. Steinbach

  96 shared

• Lillian Sung

  Hospital for Sick Children

  70 shared

• David C. Naftel

  University of Alabama at Birmingham

  65 shared

• Anne I. Dipchand

  University of Toronto

  65 shared

Awards & honors

• Emeritus Professor CE of Pediatrics (Infectious Diseases)
• Selected Publications

Similar researchers at University of Pennsylvania

• John Q. Trojanowskih-296
• Craig B. Thompsonh-277
• Daniel J Raderh-236