Daniel J Rader

About

Daniel J Rader, MD, is the Seymour Gray Professor of Molecular Medicine at the University of Pennsylvania's Perelman School of Medicine. He serves as the Director of the Penn Medicine BioBank and is the Associate Director of the Institute for Translational Medicine and Therapeutics. Dr. Rader is also the Chief of the Division of Translational Medicine and Human Genetics in the Department of Medicine and the Chair of the Department of Genetics. His research expertise focuses on molecular medicine, with particular interests in genetics, genomics, and translational medicine. He is involved in various academic departments and centers, contributing to the advancement of biomedical research and personalized medicine.

Research topics

• Biology
• Genetics
• Medicine
• Internal medicine
• Evolutionary biology
• Computational biology
• Endocrinology
• Computer Science
• Virology
• Pathology

Selected publications

• Mapping the human genetic architecture of COVID-19

  Nature · 2021 · 1108 citations

  . They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international coll…

  DOI

• The power of genetic diversity in genome-wide association studies of lipids

  Nature · 2021 · 1032 citations

  DOI

• A saturated map of common genetic variants associated with human height

  Nature · 2022 · 877 citations

  ) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than a…

  DOI

• Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

  Nature Genetics · 2020 · 787 citations

  DOI

• Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

  Cell Genomics · 2022 · 391 citations

  Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWAS…

  DOI

Recent grants

• NIH Grant P01HL059407

  NIH · $37.7M · 2021

• Trib1 regulation of hepatic lipid metabolism and atherogenesis

  NIH · $1.6M · 2016–2021

• NIH Grant R37HL055323

  NIH · $4.0M · 2019

Frequent coauthors

• Muredach P. Reilly

  Columbia University Irving Medical Center

  1974 shared

• Nilesh J. Samani

  Glenfield Hospital

  1510 shared

• Ruth McPherson

  University of Ottawa

  1490 shared

• John C. Chambers

  University of Cambridge

  1485 shared

• Jaspal S. Kooner

  Imperial College London

  1481 shared

• Ruth J. F. Loos

  Novo Nordisk (United States)

  1473 shared

• Håkon Håkonarson

  University of Pennsylvania

  1449 shared

• Nicholas J. Wareham

  MRC Epidemiology Unit

  1431 shared

Education

• B.A.

  Lehigh University

  1981

• M.D.

  Medical College of Pennsylvania

  1984

Awards & honors

• Seymour Gray Professor of Molecular Medicine
• Director, Penn Medicine BioBank
• Associate Director, Institute for Translational Medicine and…
• Chief, Division of Translational Medicine and Human Genetics…
• Chair, Department of Genetics

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