Craig B. Thompson

The hallmarks of cancer metabolism: Still emerging

Cell Metabolism · 2022-02-04 · 1368 citations

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Proceedings of the National Academy of Sciences · 2020-11-23 · 957 citations

Ferroptosis, a form of regulated necrosis driven by iron-dependent peroxidation of phospholipids, is regulated by cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. In this study, we found that activating mutation of phosphatidylinositol 3-kinase (PI3K) or loss of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) function, highly frequent events in human cancer, confers ferroptosis resistance in cancer cells, and that inhibition of the PI3K-AKT…

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Nature Immunology · 2020-07-13 · 545 citations

VDAC2 and Bak scarcity in liver mitochondria enables targeting hepatocarcinoma while sparing hepatocytes

Nature Communications · 2025-03-11 · 10 citations

Differences between normal tissues and invading tumors that allow tumor targeting while saving normal tissue are much sought after. Here we show that scarcity of VDAC2, and the consequent lack of Bak recruitment to mitochondria, renders hepatocyte mitochondria resistant to permeabilization by truncated Bid (tBid), a Bcl-2 Homology 3 (BH3)-only, Bcl-2 family protein. Increased VDAC2 and Bak is found in most human liver cancers and mitochondria from tumors and hepatic cancer cell lines exhibit VDA…

Rapid declines in southern Sierra Nevada fisher habitat driven by drought and wildfire

2025-02-27 · 1 citations

Forest disturbances are a natural ecological process, but climate and land-use change are altering disturbance regimes at an unprecedented rate, posing significant threats to biological communities and species of concern. Our aim was to develop an automated habitat monitoring system for the Southern Sierra Nevada Distinct Population Segment of fisher (Pekania pennanti) in California, USA to investigate long-term habitat trends and the effects of a recent megadrought and numerous megafires on fis…