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Carl H. June

Carl H. June

· Richard W. Vague Professorship

University of Pennsylvania · Rehabilitation Medicine

Active 1979–2026

h-index218
Citations201.1k
Papers1.7k605 last 5y
Funding$128.9M1 active

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Carl H. June, M.D., is the Richard W. Vague Professor in Immunotherapy at the University of Pennsylvania, Department of Pathology and Laboratory Medicine. He is also the Director of the Translational Research Program, the Center for Cellular Immunotherapies, and the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania. His research expertise focuses on lymphocyte biology, with a major translational emphasis on ex vivo T-cell engineering for cancer and HIV cell-based therapies. The June Laboratory is responsible for developing new chimeric antigen receptors (CARs) and vectors for current and proposed indications, fostering the development of students in doctoral and post-doctoral programs, and translating laboratory insights into safe and effective cancer therapies. The lab collaborates with faculty members interested in advancing biologically-focused research into clinical trials and works on enhancing the natural immune system's ability to recognize and eliminate tumor cells. His work is integrated with the broader mission of the Leonard and Madlyn Abramson Family Cancer Research Institute at the Abramson Cancer Center, which combines research, education, and patient care.

Research topics

  • Immunology
  • Medicine
  • Internal medicine
  • Biology
  • Cancer research
  • Oncology
  • Genetics
  • Bioinformatics
  • Pharmacology
  • Cell biology

Selected publications

  • Cytokine Storm

    New England Journal of Medicine · 2020-12-02 · 3160 citations

    reviewOpen accessSenior author

    Common Terminology Criteria for Adverse

    PublisherOA PDFDOI

  • Cytokine release syndrome in severe COVID-19

    Science · 2020-04-17 · 2028 citations

    articleSenior author

    Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease

    PublisherDOI

  • CRISPR-engineered T cells in patients with refractory cancer

    Science · 2020 · 1423 citations

    Senior authorCorresponding

    ), was performed to improve antitumor immunity. Adoptive transfer of engineered T cells into patients resulted in durable engraftment with edits at all three genomic loci. Although chromosomal translocations were detected, the frequency decreased over time. Modified T cells persisted for up to 9 months, suggesting that immunogenicity is minimal under these conditions and demonstrating the feasibility of CRISPR gene editing for cancer immunotherapy.

    DOI

  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

    Nature · 2022 · 894 citations

    Senior authorCorresponding
    DOI

  • Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

    Nano Letters · 2020 · 594 citations

    mRNA delivery to human T cells. A library of 24 ionizable lipids was synthesized, formulated into LNPs, and screened for luciferase mRNA delivery to Jurkat cells, revealing seven formulations capable of enhanced mRNA delivery over lipofectamine. The top-performing LNP formulation, C14-4, was selected for CAR mRNA delivery to primary human T cells. This platform induced CAR expression at levels equivalent to electroporation, with substantially reduced cytotoxicity. CAR T cells engineered via C14-…

    DOI

Recent grants

Frequent coauthors

Labs

  • June LaboratoryPI

Awards & honors

  • Richard W. Vague Professor in Immunotherapy
  • Director, Translational Research Program
  • Director, Center for Cellular Immunotherapies
  • Director, Parker Institute for Cancer Immunotherapy at the U…

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