Mustafa Mir
University of Pennsylvania · Rehabilitation Medicine
Active 2007–2024
About
Mustafa Mir, Ph.D., is an Assistant Professor of Cell and Developmental Biology at the Perelman School of Medicine, University of Pennsylvania. He is a core member of the Epigenetics Institute and a member of the Institute for Regenerative Medicine at the same institution. Dr. Mir co-directs the Advanced Core for Microscope Engineering and is affiliated with the Department of Cell and Developmental Biology. His research focuses on developing and applying advanced microscopy technologies, particularly high-resolution light-sheet microscopy, to visualize and quantify the dynamic processes underlying gene expression regulation during early embryonic development. His work involves studying living embryos in model organisms such as mice, Drosophila, and C. elegans, to analyze patterns of gene expression, chromatin dynamics, and protein domain distribution related to gene activation and repression. Dr. Mir's lab combines imaging approaches with biophysical modeling, genomics, and gene editing to investigate how protein-protein interactions influence nuclear organization, how nuclear architecture changes during development, and how disordered protein domains enable specialized functions. His goal is to utilize quantitative data and mechanistic modeling to develop strategies for manipulating nuclear organization and transcriptional regulation, with the aim of advancing understanding of fundamental biological processes and potential therapeutic interventions.
Research topics
- Biology
- Cell biology
- Computer science
- Genetics
- Optics
Recent grants
Quantifying the dynamics of gene regulation and nuclear organization during embryogenesis
NIH · $2.6M · 2021–2026
Frequent coauthors
- 28 shared
Gabriel Popescu
- 24 shared
Xavier Darzacq
Berkeley College
- 24 shared
Apratim Mukherjee
Children's Hospital of Philadelphia
- 16 shared
Alan P. Boka
University of Pennsylvania
- 12 shared
Gabriela Hayward-Lara
Princeton University
- 12 shared
Kaeli M. Mathias
University of Pennsylvania
- 12 shared
Liling Wan
University of Pennsylvania
- 9 shared
Mohamed El Beheiry
Centre National de la Recherche Scientifique
Labs
Mustafa Mir LabPI
Education
- 2013
PhD, Electrical and Computer Engineering
University of Illinois at Urbana-Champaign
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