Emery Bresnick

About

Emery Bresnick is the Gary Felsenfeld Professor of Cell and Regenerative Biology, the Lowell and Gwendolyn Smythe Endowed Professor, and the Director of the UW-Madison Blood Cancer Research Program. His research interests include cancer predisposition mechanisms, epigenetics, hematology, genomics, and stem/progenitor cell biology. His work focuses on understanding the epigenetic and genomic factors involved in blood cancer development and stem cell regulation, contributing to the advancement of precision medicine and regenerative biology.

Research topics

• Genetics
• Biology
• Immunology
• Medicine
• Pathology
• Cancer research
• Cell biology

Selected publications

• Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms

  Cell stem cell · 2021 · 60 citations

  DOI

• Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories

  The Journal of Experimental Medicine · 2020 · 40 citations

  Senior authorCorresponding

  Stem and progenitor cell fate transitions constitute key decision points in organismal development that enable access to a developmental path or actively preclude others. Using the hematopoietic system, we analyzed the relative importance of cell fate-promoting mechanisms versus negating fate-suppressing mechanisms to engineer progenitor cells with multilineage differentiation potential. Deletion of the murine Gata2-77 enhancer, with a human equivalent that causes leukemia, downregulates the tra…

  DOI

• A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice

  Journal of Clinical Investigation · 2023-10-17 · 14 citations

  articleOpen access

  We previously demonstrated that a subset of acute myeloid leukemia (AML) patients with concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that most of these TP53 mutations are missense mutations. Here, we report that, in contrast to the mixed AML and T cell malignancy that developed in NrasG12D/+ p53-/- (NP-/-) mice, NrasG12D/+ p53R172H/+ (NPmut) mice rapidly developed inflammation-associated AML. Under the inflammatory conditions, NPmut hematopoietic stem and progeni…

  PublisherOA PDFDOI

• GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia

  Blood · 2025-01-22 · 12 citations

  articleOpen access

  ABSTRACT: Stemness-associated cell states are linked to chemotherapy resistance in acute myeloid leukemia (AML). We uncovered a direct mechanistic link between expression of the stem cell transcription factor GATA2 and drug resistance. The GATA-binding protein 2 (GATA2) plays a central role in blood stem cell generation and maintenance. We find substantial intrapatient and interpatient variability in GATA2 expression across samples from patients with AML. GATA2 expression varies by molecular sub…

  PublisherOA PDFDOI

• Linking GATA2 to myeloid dysplasia and complex cytogenetics in adult myelodysplastic neoplasm and acute myeloid leukemia

  Blood Advances · 2023-11-29 · 7 citations

  articleOpen access

  ABSTRACT: GATA binding protein 2 (GATA2) is a conserved zinc finger transcription factor that regulates the emergence and maintenance of complex genetic programs driving development and function of hematopoietic stem and progenitor cells (HSPCs). Patients born with monoallelic GATA2 mutations develop myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML), whereas acquired GATA2 mutations are reported in 3% to 5% of sporadic AML cases. The mechanisms by which aberrant GATA2 activity prom…

  PublisherOA PDFDOI

Recent grants

• Cancer Center Administration

  NIH · $99.8M · 1997–2028

• Hematopoietic Regulation via GATA Switches

  NIH · $7.5M · 2006–2029

• NIH Grant R01ES003980

  NIH · $1.4M · 1996

Frequent coauthors

• Kirby D. Johnson

  University of Wisconsin Carbone Cancer Center

  200 shared

• Koichi R. Katsumura

  Cancer Research Institute

  92 shared

• Alexandra A. Soukup

  80 shared

• Sündüz Keleş

  78 shared

• Charu Mehta

  University of Wisconsin Carbone Cancer Center

  59 shared

• Rajendran Sanalkumar

  University of Lausanne

  57 shared

• Xin Gao

  Jilin University

  53 shared

• Kyle J. Hewitt

  University of Nebraska Medical Center

  47 shared

Education

• Ph.D., Molecular and Cell Biology

  University of California, San Francisco

  1994

• B.S., Molecular and Cell Biology

  University of California, Berkeley

  1989

Similar researchers at University of Wisconsin-Madison

• Timothy J. Kamph-77
• Ricki Colmanh-47
• Bo Liuh-41