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Sunduz Keles

Sunduz Keles

· Professor

University of Wisconsin-Madison · Biostatistics and Medical Informatics

Active 2001–2026

h-index49
Citations10.1k
Papers20558 last 5y
Funding$7.2M1 active

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Professor Sunduz Keles is a core faculty member at the Center for Genomic Science Innovation at the University of Wisconsin–Madison. Her academic credentials are in Statistics, Biostatistics & Medical Informatics. Her research focuses on developing statistical genomic methods, with a particular emphasis on noncoding regulatory sequences and the effects of their variation. This work contributes to advancing the understanding of genome regulation and the impact of genetic variation beyond coding regions, which is critical for interpreting complex genomic data and its implications in biology and medicine.

Research topics

  • Biology
  • Genetics
  • Cell biology
  • Computational biology
  • Cancer research
  • Evolutionary biology
  • Endocrinology
  • Immunology

Selected publications

  • Expanded encyclopaedias of DNA elements in the human and mouse genomes

    Nature · 2020 · 2538 citations

    data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the…

    DOI

  • Perspectives on ENCODE

    Nature · 2020 · 222 citations

    . The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.

    DOI

  • Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

    Cell Metabolism · 2020 · 152 citations

    DOI

  • CTCF loss mediates unique DNA hypermethylation landscapes in human cancers

    Clinical Epigenetics · 2020 · 51 citations

    BACKGROUND: The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigenetic states through barrier insulation, the impact of CTCF loss on genome-wide DNA methylation sites in human cancer remains undefined. RESULTS: Here, we demonstrate that prostate and breast cancers within The Cancer Genome Atlas (TCGA) exhibit frequent copy number loss of CTCF a…

    DOI

  • Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories

    The Journal of Experimental Medicine · 2020 · 40 citations

    Stem and progenitor cell fate transitions constitute key decision points in organismal development that enable access to a developmental path or actively preclude others. Using the hematopoietic system, we analyzed the relative importance of cell fate-promoting mechanisms versus negating fate-suppressing mechanisms to engineer progenitor cells with multilineage differentiation potential. Deletion of the murine Gata2-77 enhancer, with a human equivalent that causes leukemia, downregulates the tra…

    DOI

Recent grants

Frequent coauthors

Education

  • Ph.D., Biostatistics

    University of Wisconsin–Madison

    2004

  • M.S., Biostatistics

    University of Wisconsin–Madison

    2001

  • B.S., Mathematics

    University of Wisconsin–Madison

    1998

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