Bo Liu

About

Bo Liu is a Professor at the University of Wisconsin–Madison in the Department of Cell and Regenerative Biology. His research focuses on the biology of blood vessels, inflammation, intracellular signaling, cell death, cell-cell communications, and extracellular matrix protein biology. Through his work, Professor Liu investigates the complex interactions and mechanisms that regulate vascular biology and the inflammatory processes associated with it. His expertise encompasses understanding how cells communicate and respond to their environment, particularly in the context of blood vessel function and pathology. This research contributes to the broader field of regenerative biology and medicine by elucidating key cellular and molecular pathways involved in vascular health and disease.

Research topics

• Biology
• Cell biology
• Cardiology
• Internal medicine
• Medicine
• Surgery
• Genetics
• Immunology

Selected publications

• Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

  AJP Heart and Circulatory Physiology · 2020 · 92 citations

  1st authorCorresponding

  Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related mortalities are estimated at ∼200,000 deaths per year worldwide. Because no pharmacological treatment has been found to be effective so far, surgical repair remains the only treatment for aortic aneurysm. Aortic aneurysm results from changes in the aortic wall structure due to loss of smooth muscle cells and degradation of t…

  DOI

• DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs

  Science Immunology · 2021 · 50 citations

  Detection of microbial products by multiprotein complexes known as inflammasomes is pivotal to host defense against pathogens. Nucleotide-binding domain leucine-rich repeat (NLR) CARD domain containing 4 (NLRC4) forms an inflammasome in response to bacterial products; this requires their detection by NLR family apoptosis inhibitory proteins (NAIPs), with which NLRC4 physically associates. However, the mechanisms underlying sterile NLRC4 inflammasome activation, which is implicated in chronic non…

  DOI

• Thrombospondin-1 in vascular development, vascular function, and vascular disease

  Seminars in Cell and Developmental Biology · 2023-07-27 · 35 citations

  reviewOpen access1st authorCorresponding
  PublisherOA PDFDOI

• A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing

  Communications Biology · 2023-01-31 · 24 citations

  articleOpen accessSenior authorCorresponding

  Deep vein thrombosis (DVT) is a common clinical problem, but its cellular and molecular mechanisms remain incompletely understood. In this study, we performed single-cell RNA sequencing on mouse inferior vena cava (IVC) 24 h after thrombus-inducing IVC ligation or sham operation. 9 cell types composed of multiple subpopulations were identified. Notable transcriptomic changes induced by DVT included a marked inflammatory response, elevated hypoxia, and globally reduced myogenesis. Analysis of ind…

  PublisherOA PDFDOI

• Thrombosis in the pathogenesis of abdominal aortic aneurysm

  JVS Vascular Science · 2023-01-01 · 19 citations

  reviewOpen accessSenior authorCorresponding

  Background: Abdominal aortic aneurysms (AAAs) are a relatively common vascular pathology of the elderly with high morbidity potential. Irreversible degeneration of the aortic wall leads to lethal rupture if left untreated. Nearly all AAAs contain intraluminal thrombus (ILT) to a varying degree, yet the mechanisms explaining how thrombosis is disturbed in AAA are relatively unknown. This review examined the thrombotic complications associated with AAA, the impact of thrombosis on AAA surgical out…

  PublisherDOI

Recent grants

• Novel Role of Thrombospondin-1 in Protection against Rupture of Abdominal Aortic Aneurysm

  NIH · $514k · 2021–2025

• Molecular Mechanisms in Abdominal Aortic Aneuysm

  NIH · $3.2M · 2010–2022

• Molecular Mechanisms in Abdominal Aortic Aneuysm

  NIH · $117k · 2010–2021

Frequent coauthors

• K. Craig Kent

  University of Virginia

  50 shared

• Jun Ren

  Children's Hospital of Chongqing Medical University

  37 shared

• Shirling Tsai

  36 shared

• Qiwei Wang

  32 shared

• Stephanie Morgan

  28 shared

• Dai Yamanouchi

  University of Wisconsin–Madison

  22 shared

• Ting Zhou

  Huazhong University of Science and Technology

  18 shared

• Huan Yang

  Harvard University

  17 shared

Labs

• Liu Vascular Research LaboratoryPI

Education

• PhD, Biochemistry

  State University of New York

  1992

Similar researchers at University of Wisconsin-Madison

• Timothy J. Kamph-77
• Emery Bresnickh-60
• Ricki Colmanh-47