Xin Gao

About

Xin Gao, PhD, is an Assistant Professor who obtained her PhD from the University of Wisconsin-Madison in 2016, working in Emery Bresnick’s lab. Following her doctoral studies, she completed two postdoctoral fellowships: one at Albert Einstein College of Medicine in Paul Frenette's lab, and another at UW-Madison in Jing Zhang's lab. Dr. Gao has been recognized with a K01 award and the ASH Fellow-to-Faculty Scholar Award, which have supported her research focusing on the bone marrow microenvironment and hematopoietic stem cells. She joined the faculty at UW-Madison in 2023.

Research topics

• Biology
• Immunology
• Cancer research
• Genetics
• Cell biology

Selected publications

• <i>Asxl1</i> loss cooperates with oncogenic <i>Nras</i> in mice to reprogram the immune microenvironment and drive leukemic transformation

  Blood · 2021 · 56 citations

  Mutations in chromatin regulator ASXL1 are frequently identified in myeloid malignancies, in particular ∼40% of patients with chronic myelomonocytic leukemia (CMML). ASXL1 mutations are associated with poor prognosis in CMML and significantly co-occur with NRAS mutations. Here, we show that concurrent ASXL1 and NRAS mutations defined a population of CMML patients who had shorter leukemia-free survival than those with ASXL1 mutation only. Corroborating this human data, Asxl1-/- accelerated CMML p…

  DOI

• A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice

  Journal of Clinical Investigation · 2023-10-17 · 14 citations

  articleOpen access

  We previously demonstrated that a subset of acute myeloid leukemia (AML) patients with concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that most of these TP53 mutations are missense mutations. Here, we report that, in contrast to the mixed AML and T cell malignancy that developed in NrasG12D/+ p53-/- (NP-/-) mice, NrasG12D/+ p53R172H/+ (NPmut) mice rapidly developed inflammation-associated AML. Under the inflammatory conditions, NPmut hematopoietic stem and progeni…

  PublisherOA PDFDOI

• Data from Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing

  2024-09-03

  preprintOpen access

  &lt;div&gt;AbstractPurpose:&lt;p&gt;In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important hindrances toward a cure for MM. To further understand the molecular mechanisms controlling the clonal evolution of MM, we applied single-cell RNA sequencing (scRNA-seq) to paired diagnostic and posttreatment bone marrow (BM) samples.&lt;/p&gt;Experimental Design:&lt;p&gt;scRNA-seq was performed on 38 BM samples from patients with…

  PublisherDOI

• Data from Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing

  2024-09-03

  preprintOpen access

  &lt;div&gt;AbstractPurpose:&lt;p&gt;In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important hindrances toward a cure for MM. To further understand the molecular mechanisms controlling the clonal evolution of MM, we applied single-cell RNA sequencing (scRNA-seq) to paired diagnostic and posttreatment bone marrow (BM) samples.&lt;/p&gt;Experimental Design:&lt;p&gt;scRNA-seq was performed on 38 BM samples from patients with…

  PublisherDOI

• Supplementary Data 2 from Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing

  2024-09-03

  preprintOpen access

  &lt;p&gt;Supplemental table 1-15.&lt;/p&gt;

  PublisherDOI

Frequent coauthors

• Shaoshan Hu

  Harbin Medical University

  61 shared

• Hang Ji

  Sichuan University

  56 shared

• Emery H. Bresnick

  University of Wisconsin Carbone Cancer Center

  53 shared

• Jiheng Zhang

  Harbin Medical University

  46 shared

• Jianyang Du

  Zhejiang Provincial People's Hospital

  46 shared

• Kirby D. Johnson

  University of Wisconsin Carbone Cancer Center

  45 shared

• Zhihui Liu

  Liaoning Provincial People's Hospital

  45 shared

• Nan Wang

  Minzu University of China

  42 shared

Labs

• Gao LabPI

Similar researchers at University of Wisconsin-Madison

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• Rudolph C. Johnsonh-65
• Wei Huangh-62