Weibo Cai

About

Weibo Cai is an Affiliate Professor at the School of Pharmacy and a Professor of Radiology at the School of Medicine and Public Health at the University of Wisconsin-Madison. His research focuses on biomedical nanotechnology and molecular imaging, primarily utilizing positron emission tomography and multimodal imaging techniques. He is involved in image-guided drug delivery, theranostics, translational research, tumor targeting, and cancer diagnosis and therapy. Additionally, his work encompasses imaging of cardiovascular diseases and diabetes, contributing to advancements in medical imaging and targeted treatment strategies.

Research topics

• Medicine
• Nanotechnology
• Materials science
• Chemistry
• Internal medicine
• Political Science
• Cancer research
• Pharmacology
• Biochemistry
• Computer Science

Selected publications

• In vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice

  2020 · 1215 citations

  The fate and biological effects of carbon nanotubes in animals are critical to potential applications in vivo. Efficient targeting of integrin positive –tumour in mice is achieved with Single-walled carbon nanotubes (SWNTs) coated with poly(ethylene glycol) chains linked to an arginine–glycine–aspartic acid peptide. A high tumour accumulation is attributed to the multivalent effect of the SWNTs. The Raman signatures of SWNTs are used to directly probe the presence of nanotubes in mice tissues an…

  DOI

• ImmunoPET: Concept, Design, and Applications

  Chemical Reviews · 2020 · 462 citations

  Senior authorCorresponding

  Zr-atezolizumab, have been successfully translated for clinical use. By noninvasively and dynamically revealing the expression of heterogeneous tumor antigens, immunoPET imaging is gradually changing the theranostic landscape of several types of malignancies. ImmunoPET is the method of choice for imaging specific tumor markers, immune cells, immune checkpoints, and inflammatory processes. Furthermore, the integration of immunoPET imaging in antibody drug development is of substantial significanc…

  DOI

• Selenium‐Doped Carbon Quantum Dots Act as Broad‐Spectrum Antioxidants for Acute Kidney Injury Management

  Advanced Science · 2020 · 209 citations

  Senior authorCorresponding

  The manifestation of acute kidney injury (AKI) is associated with poor patient outcomes, with treatment options limited to hydration or renal replacement therapies. The onset of AKI is often associated with a surfeit of reactive oxygen species. Here, it is shown that selenium-doped carbon quantum dots (SeCQDs) have broad-spectrum antioxidant properties and prominent renal accumulation in both healthy and AKI mice. Due to these properties, SeCQDs treat or prevent two clinically relevant cases of…

  DOI

• Nanomaterial-based contrast agents

  Nature Reviews Methods Primers · 2023 · 113 citations

  PublisherOA PDFDOI

• Open‐Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy

  Advanced Materials · 2022 · 108 citations

  to generate Cu(I)NS, leading to a singlet ground state and recuperative sonosensitivity. Additionally, PEG endows Cu(II)NS with increased blood biological half-life and enhanced tumor accumulation, further increasing the effect of SDT. Through regulating the valence state of Cu, cancer SDT with enhanced therapeutic index is achieved.

  DOI

Recent grants

• NIH Grant R01CA169365

  NIH · $602k · 2017

• Ultrasound-Activated Piezoelectric P(VDF-TrFE) Nanoparticles for Electric Ablation of Cancer Cells

  NIH · $413k · 2019–2022

• NIH Grant R01CA16936501A1

  NIH · $302k · 2016

Frequent coauthors

• Todd E. Barnhart

  University of Wisconsin–Madison

  240 shared

• Jonathan W. Engle

  University of Wisconsin–Madison

  200 shared

• Dawei Jiang

  192 shared

• Hao Hong

  North China Electric Power University

  180 shared

• Shreya Goel

  University of Utah

  127 shared

• Stephen A. Graves

  University of Iowa

  113 shared

• Reinier Hernandez

  University of Wisconsin–Madison

  110 shared

• Hector F. Valdovinos

  Lawrence Livermore National Laboratory

  102 shared

Labs

• Weibo Cai LabPI

  Not provided

Similar researchers at University of Wisconsin-Madison

• Jeffrey Johnsonh-109
• Quanyin Huh-95
• Glen Kwonh-66