Johnathan Engle
· Associate ProfessorUniversity of Wisconsin-Madison · Radiology
Active 1972–2026
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About
Jonathan W. Engle, PhD, is an Associate Professor in the Departments of Medical Physics and Radiology at the University of Wisconsin. He specializes in radionuclide production, accelerator targetry, and radiochemistry, functioning as an analytical and preparative radiochemist in clinical and pre-clinical positron emission tomography (PET) scanning environments. Dr. Engle is involved in constructing automated radiochemistry modules for routine and novel syntheses and in advancing PET radiotracer production facilities from basic setups to routine production and research activities. He leads the Cyclotron Research Group, focusing on radiometals production and innovative small accelerator targetry, particularly for producing positron and Auger electron emitting radionuclides such as Zr-89, Cu-64, As-72, Y-86, Br-77, Ga-68, Co-55, and Sc-44. His research efforts include the development of new methods for radionuclide production, contributing significantly to the field of radiochemistry and medical imaging.
Research topics
- Internal medicine
- Medicine
- Pathology
- Cancer research
- Chemistry
- Nanotechnology
- Materials science
- Pharmacology
- Biochemistry
- Biology
Selected publications
Advanced Science · 2020 · 209 citations
The manifestation of acute kidney injury (AKI) is associated with poor patient outcomes, with treatment options limited to hydration or renal replacement therapies. The onset of AKI is often associated with a surfeit of reactive oxygen species. Here, it is shown that selenium-doped carbon quantum dots (SeCQDs) have broad-spectrum antioxidant properties and prominent renal accumulation in both healthy and AKI mice. Due to these properties, SeCQDs treat or prevent two clinically relevant cases of…
Open‐Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy
Advanced Materials · 2022 · 108 citations
to generate Cu(I)NS, leading to a singlet ground state and recuperative sonosensitivity. Additionally, PEG endows Cu(II)NS with increased blood biological half-life and enhanced tumor accumulation, further increasing the effect of SDT. Through regulating the valence state of Cu, cancer SDT with enhanced therapeutic index is achieved.
Amyloid duration is associated with preclinical cognitive decline and tau PET
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2020 · 89 citations
INTRODUCTION: This study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging to identify age-heterogeneous amyloid trajectory groups, estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in relation to cognitive decline and tau burden. METHODS: = 171) to identify and model amyloid trajectory groups, which were combined with Bayes theorem to estimate age and chronicity of amyloid positivity. Relationships between chr…
Theranostics · 2021 · 74 citations
We report the time course of the STING-dependent IFN1 response following radiation in multiple murine tumor models. We show the potential of TRT to stimulate IFN1 activation that is comparable to that observed with EBRT and this may be critical to the therapeutic integration of TRT with immunotherapies.
Ultrasmall Porous Silica Nanoparticles with Enhanced Pharmacokinetics for Cancer Theranostics
Nano Letters · 2021 · 59 citations
Y-DOTA-UPSN significantly inhibits tumor growth and increases overall survival, indicating the promise of UPSN for future clinical translation as a cancer theranostic agent.
Recent grants
Frequent coauthors
- 200 shared
Weibo Cai
- 199 shared
Todd E. Barnhart
University of Wisconsin–Madison
- 116 shared
Eduardo Aluicio‐Sarduy
University of Wisconsin–Madison
- 114 shared
Dawei Jiang
- 56 shared
Reinier Hernandez
University of Wisconsin–Madison
- 46 shared
Kendall E. Barrett
University of Wisconsin–Madison
- 44 shared
F.M. Nortier
Los Alamos National Laboratory
- 42 shared
Peng Huang
Sichuan Cancer Hospital
Education
- 2000
Ph.D., Radiology
University of Wisconsin–Madison
- 1996
M.S., Radiology
University of Wisconsin–Madison
- 1994
B.S., Radiology
University of Wisconsin–Madison
Awards & honors
- Department of Energy Early Career Award (2016)
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