Vincent Rotello

About

Professor Vincent M. Rotello is a principal investigator in the Rotello Research Group, with a focus on interactions in chemistry. His research encompasses areas such as antimicrobials, bioorthogonal chemistry, drug delivery, and sensing. He is recognized as a top researcher globally and has delivered plenary talks at major conferences such as the ACS Fall 2025. His work is dedicated to advancing understanding and innovation in chemical interactions, contributing significantly to the fields of chemical biology and materials science.

Research topics

• Nanotechnology
• Biology
• Materials science
• Microbiology
• Cancer research
• Oncology
• Computational biology
• Chemistry
• Medicine
• Internal medicine

Selected publications

• Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

  Nature Reviews Microbiology · 2020 · 1325 citations

  Senior authorCorresponding
  DOI

• Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

  Advanced Drug Delivery Reviews · 2020 · 332 citations

  Senior authorCorresponding
  DOI

• Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies

  International Journal of Environmental Research and Public Health · 2020 · 328 citations

  Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to their highly invasive nature and relatively low response to therapeutics. There is an absence of specific treatment strategies for this tumor subgroup, and hence TNBC is managed with conventional therapeutics, often leading to systemic relapse. In terms of histology and transcription profile these cancers have similariti…

  DOI

• Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions

  Materials Horizons · 2021 · 44 citations

  Senior authorCorresponding

  murine wound biofilm model. The antimicrobial activity, wound healing promotion, and biosafety of these nanoemulsions provide a readily translatable and sustainable strategy for managing wound infections.

  DOI

• Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of Candida albicans Biofilms

  Microorganisms · 2025-01-09 · 9 citations

  articleOpen accessSenior authorCorresponding

  Fungal infections represent a significant global health challenge. Candida albicans is a particularly widespread pathogen, with both molecular and biofilm-based mechanisms making it resistant to or tolerant of available antifungal drugs. This study reports a combination therapy, active against C. albicans, utilizing terbinafine and essential oils incorporated into a gelatin-based nanoemulsion system (T-GNE). Eugenol and methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol…

  PublisherOA PDFDOI

Recent grants

• Nanosensor-Based Phenotypic Screening for Precision Therapy of Cancer Stem Cells

  NIH · $300k · 2017–2019

• International Collaboration in Chemistry: Synergistic Tailoring of Flavins and Quantum Dots for Solar Cell Applications

  NSF · $425k · 2010–2014

• Plasmon-Enhanced Chiroptical Biosensors

  NSF · $400k · 2013–2017

Frequent coauthors

• Graeme Cooke

  University of Glasgow

  129 shared

• Paul S. Weiss

  California NanoSystems Institute

  91 shared

• Scott J. Miller

  NextFlex

  85 shared

• Jonathan V. Sweedler

  University of Illinois Urbana-Champaign

  85 shared

• Hongwei Wu

  85 shared

• Lynne S. Taylor

  Purdue University West Lafayette

  85 shared

• Harry A. Atwater

  California Institute of Technology

  85 shared

• J. Justin Gooding

  UNSW Sydney

  85 shared

Labs

• Rotello Research GroupPI

Education

• Postdoc, Chemistry

  Massachusetts Institute of Technology

  1993

• Ph.D., Chemistry

  Yale University

  1990

• Bachelor of Science, Chemistry

  Illinois Institute of Technology

  1985

Awards & honors

• NSF CAREER
• Cottrell Scholar awards
• Camille Dreyfus Teacher-Scholar
• Sloan Fellowships
• Arthur C. Cope Scholar Award (2023)

Similar researchers at University of Massachusetts Amherst

• Steve Granickh-99
• Zhu Chenh-85
• Wei Fanh-68