Scott Miller

About

Scott Miller is a Sterling Professor of Chemistry and a member of the Yale faculty since 2006. His research focuses on molecular synthesis, particularly the development of new methods for the synthesis and derivatization of complex structures. His group employs reaction design, development, and application, utilizing principles from biologically relevant structures and processes to discover new reactions and apply new principles to the selective synthesis of complex molecules. Miller's work involves the use of modern synthetic chemistry techniques, rational design, combinatorial screening, and mechanistic analysis to discover new chemical transformations that enable rapid synthesis of stereochemically complex structures and the development of new catalysts for selective functionalization, including the catalytic modification of natural products. His contributions have significantly advanced the field of organic chemistry, earning him international recognition and numerous awards.

Research topics

• Combinatorial chemistry
• Chemistry
• Stereochemistry
• Biochemistry
• Pharmacology
• Computer Science
• Biology
• Biochemical engineering
• Genetics
• Library science

Selected publications

• Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations

  ACS Central Science · 2021 · 259 citations

  . Results of cell-based antiviral assays further demonstrated the potential of the compounds for treatment of COVID-19. In addition to the possible therapeutic significance, the work clearly demonstrates the power of computational chemistry for drug discovery, especially FEP-guided lead optimization.

  DOI

• Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms

  Chemical Reviews · 2020 · 219 citations

  Senior authorCorresponding

  , 107, 5759-5812). The overarching goal of this new Review is to provide a comprehensive account of the numerous advances in the field. As a corollary to this goal, we survey the many different types of catalytic reactions, ranging from acylation to C-C bond formation, in which peptides have been successfully employed. In so doing, we devote significant discussion to the structural and mechanistic aspects of these reactions that are perhaps specific to peptide-based catalysts and their interacti…

  DOI

• Catalytic Dynamic Kinetic Resolutions in Tandem to Construct Two-Axis Terphenyl Atropisomers

  Journal of the American Chemical Society · 2020 · 99 citations

  Senior authorCorresponding

  -symmetric phosphoric acids allows catalyst control in the second stereochemistry-determining event. Accordingly, we established the fully catalyst-controlled stereodivergent synthesis of all possible chlorinated stereoisomers while also demonstrating diastereodivergence in the brominated variants, with significant levels of enantioselectivity in all cases.

  DOI

• Green Chemistry: A Framework for a Sustainable Future

  Organic Process Research & Development · 2021 · 86 citations

  ADVERTISEMENT RETURN TO ISSUEEditorialNEXTGreen Chemistry: A Framework for a Sustainable FutureKrishna N. GaneshKrishna N. GaneshMore by Krishna N. Ganeshhttps://orcid.org/0000-0003-2292-643X, Deqing ZhangDeqing ZhangMore by Deqing Zhanghttps://orcid.org/0000-0002-5709-6088, Scott J. MillerScott J. MillerMore by Scott J. Millerhttps://orcid.org/0000-0001-7817-1318, Kai RossenKai RossenMore by Kai Rossenhttps://orcid.org/0000-0002-3857-0004, Paul J. ChirikPaul J. ChirikMore by Paul J. Chirikhttps…

  DOI

• Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

  Structure · 2021 · 63 citations

  DOI

Recent grants

• Minimal Peptide Catalysts for Asymmetric Synthesis

  NSF · $424k · 2006–2009

• Site-Selective Catalysis for Organic Synthesis

  NIH · $2.7M · 2003–2021

• Site-Selective Catalysis for Bioactive Scaffold Diversification

  NIH · $5.5M · 2019–2029

Frequent coauthors

• Alanna Schepartz

  Arc Research Institute

  118 shared

• Paul J. Chirik

  105 shared

• Brandon Q. Mercado

  Yale University

  98 shared

• Kai Rossen

  96 shared

• Bryan W. Brooks

  Baylor University

  94 shared

• Krishna N. Ganesh

  Jawaharlal Nehru Centre for Advanced Scientific Research

  94 shared

• David T. Allen

  Center for Environmental Health

  94 shared

• Phillip E. Savage

  Pennsylvania State University

  94 shared

Education

• National Science Foundation Postdoctoral Fellow, Department of Chemistry

  California Institute of Technology

  1996

• Ph.D., Department of Chemistry

  Harvard University

  1994

• B.A. and M.A., Department of Chemistry

  Harvard University

  1989

Awards & honors

• Research Innovation Award, Research Corporation (1998)
• NSF CAREER Award (1999)
• Cottrell Scholar Award of Research Corporation (1999)
• Eli Lilly Grantee (1999)
• Novartis Chemistry Lectureship Award (1999)

Similar researchers at Yale University

• William Jorgensenh-123
• Jon Ellmanh-111
• Patrick Hollandh-92