Jonathan V. Sweedler
· James R. Eiszner Family Endowed Chair in ChemistryUniversity of Illinois Urbana-Champaign · Bioengineering
Active 1987–2026
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About
Jonathan V. Sweedler is the James R. Eiszner Endowed Chair and Professor in the Department of Bioengineering at the University of Illinois Urbana-Champaign. His primary research focuses on micro and molecular technologies, specifically chemical biosensors, high-throughput analysis, and instrumentation. He is involved in advancing bioengineering through the development of innovative tools and techniques for detecting and treating health issues, with a particular emphasis on neurochemistry and chemical biosensors. His work contributes to understanding complex biological systems and improving health-related diagnostics and therapies.
Research topics
- Chemistry
- Computer Science
- Chromatography
- Materials science
- Nanotechnology
- Biology
- Computational biology
- Cell biology
- Optoelectronics
- Neuroscience
Selected publications
Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization
Nature Methods · 2021 · 90 citations
Senior authorCorrespondingPeptidergic dense-core vesicles are involved in packaging and releasing neuropeptides and peptide hormones-critical processes underlying brain, endocrine and exocrine function. Yet, the heterogeneity within these organelles, even for morphologically defined vesicle types, is not well characterized because of their small volumes. We present image-guided, high-throughput mass spectrometry-based protocols to chemically profile large populations of both dense-core vesicles and lucent vesicles for th…
Single-Cell Classification Using Mass Spectrometry through Interpretable Machine Learning
Analytical Chemistry · 2020 · 80 citations
Senior authorCorrespondingThe brain consists of organized ensembles of cells that exhibit distinct morphologies, cellular connectivity, and dynamic biochemistries that control the executive functions of an organism. However, the relationships between chemical heterogeneity, cell function, and phenotype are not always understood. Recent advancements in matrix-assisted laser desorption/ionization mass spectrometry have enabled the high-throughput, multiplexed chemical analysis of single cells, capable of resolving hundreds…
Advanced Functional Materials · 2021 · 64 citations
electrophysiological recording platforms.
Single cell metabolism: current and future trends
Metabolomics · 2022 · 57 citations
Proceedings of the National Academy of Sciences · 2024 · 36 citations
Myokines and exosomes, originating from skeletal muscle, are shown to play a significant role in maintaining brain homeostasis. While exercise has been reported to promote muscle secretion, little is known about the effects of neuronal innervation and activity on the yield and molecular composition of biologically active molecules from muscle. As neuromuscular diseases and disabilities associated with denervation impact muscle metabolism, we hypothesize that neuronal innervation and firing may p…
Recent grants
Chemical-imaging guided characterization of cellular populations
NSF · $405k · 2016–2019
Molecular Profiling & Characterization
NIH · $18.2M · 2004–2029
NIH · $289k · 2004
Frequent coauthors
- 200 shared
Stanislav S. Rubakhin
University of Illinois Urbana-Champaign
- 98 shared
Elena V. Romanova
University of Illinois Urbana-Champaign
- 89 shared
Joan‐Emma Shea
University of California, Santa Barbara
- 87 shared
Paul W. Bohn
University of Notre Dame
- 85 shared
Bin Liu
- 85 shared
Marc A. Hillmyer
University of Minnesota
- 85 shared
Joel D. Blum
University of Michigan–Ann Arbor
- 85 shared
Kai Rossen
Labs
Sweedler Research GroupPI
Education
- 1991
Ph.D., Bioengineering
University of Illinois at Urbana-Champaign
- 1987
M.S., Bioengineering
University of Illinois at Urbana-Champaign
- 1985
B.S., Bioengineering
University of Illinois at Urbana-Champaign
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