Shuming Nie

About

Professor Shuming Nie is the Grainger Distinguished Chair in Engineering and a Professor of Bioengineering, Chemistry, Materials Science and Engineering, Electrical and Computer Engineering at the University of Illinois at Urbana-Champaign. He is also the Founding Dean of the College of Engineering and Applied Sciences at Nanjing University in China. His academic research primarily focuses on nanomedicine, image-guided cancer surgery, cell-based immunotherapy, wearable optoelectronic devices, and digital health. His major achievements include the discovery of colloidal metal nanoparticles that significantly amplify surface-enhanced Raman scattering (SERS), pioneering work on water-soluble semiconductor quantum dots for biomedical applications, and developing multifunctional smart nanoparticles for integrated biomedical imaging and therapy, including image-guided cancer surgery. Professor Nie has published over 300 papers, holds numerous patents, and has delivered nearly 500 invited lectures worldwide. His scholarly work has been cited more than 100,000 times, with an H-index of 113. He received his BS from Nankai University in China, and his MS and PhD from Northwestern University, with postdoctoral research at Georgia Tech and Stanford University.

Research topics

• Internal medicine
• Medicine
• Chemistry
• Nanotechnology
• Materials science

Selected publications

• Surface-enhanced Raman spectroscopy: a half-century historical perspective

  Chemical Society Reviews · 2024-12-23 · 276 citations

  reviewOpen access

  Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and plasmonics, and highlighting collective contributions of key pioneers. (2) Classifying four pivotal phases from the view of innovative methodologies in the fifty-year progression:…

  PublisherDOI

• Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

  ACS Applied Materials & Interfaces · 2025-02-24 · 167 citations

  reviewOpen access

  deep Raman spectroscopy, emphasizing its potential for liquid biopsy, metabolic phenotyping, and extracellular vesicle diagnostics. The review concludes with a perspective on clinical translation of SERS, addressing commercialization potentials and the challenges in deep tissue in vivo sensing and imaging.

  PublisherOA PDFDOI

• Efficient and Stable Thin‐Film Luminescent Solar Concentrators Enabled by Near‐Infrared Emission Perovskite Nanocrystals

  Angewandte Chemie International Edition · 2020-01-30 · 96 citations

  article

  Abstract A novel triphenylphosphine (TPP) treatment strategy was developed to prepare the near‐infrared emission CsPbI 3 nanocrystal (NC)‐polymer composite thin‐film luminescent solar concentrators (LSCs) featuring high absolute photoluminescence quantum yield (PLQY), low reabsorption, and high stability. The PL emission of the LSCs is centered at about 700 nm with 99.4±0.4 % PLQY and narrow full width at half maximum (FWHM) of 75 meV (30 nm). Compared with LSCs prepared with classic CsPbI 3 NCs…

  PublisherDOI

• Properties of Carbon Dots versus Small Molecules from “Bottom-up” Synthesis

  ACS Nano · 2023-11-16 · 65 citations

  article

  A major challenge in the "bottom-up" solvothermal synthesis of carbon dots (CDs) is the removal of small-molecule byproducts, noncarbonized polyamides, or other impurities that confound the optical properties. In previously reported benzene diamine-based CDs, the observed fluorescence signal already has been shown to arise from free small molecules, not from nanosized carbonized dots. Here we have unambiguously identified the small-molecule species in the synthesis of CDs starting with several i…

  PublisherDOI

• Biomimetic Surface-Enhanced Raman Scattering Nanoparticles with Improved Dispersibility, Signal Brightness, and Tumor Targeting Functions

  ACS Nano · 2022 · 56 citations

  Senior authorCorresponding

  The development of biocompatible and nontoxic surface-enhanced Raman scattering (SERS) nanoparticles is of considerable current interest because of their attractive biomedical applications such as ultrasensitive in vitro diagnostics, in vivo tumor imaging, and spectroscopy-guided cancer surgery. However, current SERS nanoparticles are prepared and stored in aqueous solution, have limited stability and dispersibility, and are not suitable for lyophilization and storage by freeze-drying or other m…

  DOI

Recent grants

• NIH Grant R01GM060562

  NIH · $805k · 2005

• NIH Grant R01CA163256

  NIH · $5.1M · 2018

• NIH Grant R01GM058173

  NIH · $819k · 2005

Frequent coauthors

• Andrew M. Smith

  University of Illinois Urbana-Champaign

  99 shared

• Xiaohu Gao

  East China Jiaotong University

  80 shared

• May D. Wang

  56 shared

• Yiqing Wang

  Nanjing University

  55 shared

• Nai‐Teng Yu

  Microscan Systems (United States)

  52 shared

• Sunil Singhal

  49 shared

• Ximei Qian

  Emory University

  43 shared

• Amit Agrawal

  All India Institute of Medical Sciences Bhopal

  41 shared

Awards & honors

• Grainger Distinguished Chair in Engineering, University of I…
• Fellow of AAAS
• Fellow of AIMBE
• Fellow of IAMBE

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