Thomas De Raedt
University of Pennsylvania · Rehabilitation Medicine
Active 2003–2024
About
Thomas De Raedt, PhD, is an Assistant Professor of Pediatrics (Oncology) in the Department of Pediatrics at the Perelman School of Medicine, University of Pennsylvania, affiliated with Children's Hospital Philadelphia. His research focuses on elucidating the mechanisms by which pediatric High Grade Gliomas develop and progress. His lab aims to understand crucial pathways involved in tumor development, their interactions, and how these insights can be exploited to develop novel therapies. To achieve this, his team molecularly analyzes human tumor samples, conducts cellular studies, and develops accurate in vitro and in vivo models. They perform high-quality pre-clinical studies in animal models with the goal of translating successful findings into clinical applications, which has led to multiple ongoing clinical trials. De Raedt's work particularly concentrates on pediatric High Grade Glioma (pHGG), a devastating disease with a median survival of approximately 12 months. His research emphasizes the role of the RAS pathway, especially in tumors driven by aberrant activation of this pathway, such as through loss of NF1. His lab investigates how mutations in epigenetic machinery co-occur with RAS pathway mutations and explores the cooperation between these genetic alterations. His team develops advanced in vivo models and tools to functionally identify and understand epigenetic drivers like ATRX, and how they cooperate with RAS pathway activation. Additionally, his research includes developing therapeutic strategies, including cellular and immunotherapies, such as cellular delivery systems derived from migratory interneuron precursors and Peptide-Centric Chimeric Antigen Receptors (PC-CARs) targeting NF1-associated tumors. His work also involves exploring new therapies through drug screening and innovative cellular therapies to improve outcomes for glioma patients.
Research topics
- Cancer research
- Biology
- Medicine
- Cell biology
- Genetics
Frequent coauthors
- 117 shared
Karen Cichowski
- 105 shared
Éric Pasmant
Université Paris Cité
- 103 shared
Armelle Luscan
Sorbonne Université
- 103 shared
Michel Vidaud
Sorbonne Université
- 103 shared
Nicolás Ortonne
- 99 shared
Dominique Vidaud
- 98 shared
P. Wolkenstein
- 96 shared
Laurent Lantieri
Labs
De Raedt LabPI
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