Thomas A. Wadden

About

Thomas A. Wadden is an Emeritus Professor of Psychiatry at the University of Pennsylvania. He serves as the Director of the Center for Weight and Eating Disorders within the Department of Psychiatry. His educational background includes an A.B. in Psychology from Brown University and a Ph.D. in Psychology from the University of North Carolina. He also holds an honorary M.A. from the University of Pennsylvania. His professional work focuses on obesity treatment, lifestyle modification, and behavioral therapy related to weight management. Dr. Wadden has contributed to research on obesity treatment in primary care practice, weight maintenance, and the behavioral aspects of obesity management, with numerous publications in these areas.

Research topics

• Internal medicine
• Endocrinology
• Medicine
• Pediatrics
• Physical therapy

Selected publications

• Once-Weekly Semaglutide in Adults with Overweight or Obesity

  New England Journal of Medicine · 2021-02-10 · 4417 citations

  articleOpen access

  BACKGROUND: Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed. METHODS: In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided by the square of the height in meters) of 30 or greater (≥27 in persons with ≥1 weight-related coexisting condition), who did not have di…

  PublisherOA PDFDOI

• Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

  The Lancet · 2021-03-01 · 1281 citations

  articleOpen access
  PublisherOA PDFDOI

• Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity

  JAMA · 2021-03-23 · 1227 citations

  articleOpen access

  Importance: The effect of continuing vs withdrawing treatment with semaglutide, a glucagon-like peptide 1 receptor agonist, on weight loss maintenance in people with overweight or obesity is unknown. Objective: To compare continued once-weekly treatment with subcutaneous semaglutide, 2.4 mg, with switch to placebo for weight maintenance (both with lifestyle intervention) in adults with overweight or obesity after a 20-week run-in with subcutaneous semaglutide titrated to 2.4 mg weekly. Design, S…

  PublisherOA PDFDOI

• Effects of Weight Loss on Obstructive Sleep Apnea Severity. Ten-Year Results of the Sleep AHEAD Study

  American Journal of Respiratory and Critical Care Medicine · 2020 · 137 citations

  Participants with OSA and type 2 diabetes mellitus receiving ILI for weight loss had reduced OSA severity at 10 years. No difference in OSA severity was present between ILI and DSE groups at 10 years. Improvement in OSA severity over the 10-year period with ILI was related to change in body weight, baseline AHI, and intervention independent of weight change.

  DOI

• Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity

  New England Journal of Medicine · 2025-06-22 · 132 citations

  article

  BACKGROUND: Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg has shown promising results in early-phase trials; the efficacy of the combination (known as CagriSema) on weight loss in persons with either overweight and coexisting conditions or obesity is unknown. METHODS: In a phase 3a, 68-week, multicenter, double-blind, placebo-controlled and active-controlled trial, we enrolled adults without diabetes who had a body-m…

  PublisherDOI

Recent grants

• NIH Grant R01DK056124

  NIH · $1.9M · 2003

• NIH Grant R01HD020152

  NIH · $179k · 1988

• NIH Grant R01HL070301

  NIH · $6.3M · 2014

Frequent coauthors

• Rena R. Wing

  Miriam Hospital

  186 shared

• David B. Sarwer

  Temple University

  162 shared

• Samuel T. Kuna

  Philadelphia VA Medical Center

  119 shared

• Jesse Chittams

  University of Pennsylvania

  115 shared

• Robert I. Berkowitz

  University of Pennsylvania

  113 shared

• Karen Johnson

  University of Tennessee Health Science Center

  111 shared

• Julio A. Chirinos

  University of Pennsylvania

  109 shared

• Indira Gurubhagavatula

  University of Pennsylvania

  109 shared

Similar researchers at University of Pennsylvania

• John Q. Trojanowskih-296
• Craig B. Thompsonh-277
• Daniel J Raderh-236