Julio A. Chirinos

About

Julio A. Chirinos, MD, PhD, is a Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania. He serves as an Attending Physician at the Hospital of the University of Pennsylvania and is an Adjunct Faculty member at the Center for Magnetic Resonance and Optimal Imaging at the University of Pennsylvania. Dr. Chirinos is also the Co-Director of the Training Program in Cardiovascular Biology and Medicine, Clinical/Translational Science at the University of Pennsylvania Perelman School of Medicine. His research expertise includes non-invasive cardiac imaging, arterial stiffness and hemodynamics, ventricular-vascular interactions, and the cardiovascular consequences of obstructive sleep apnea. His clinical expertise encompasses echocardiography and cardiac MRI. Dr. Chirinos completed his medical education at the Catholic University of Santa Maria School of Human Medicine in 1999 and earned a PhD in Biomedical Sciences from the University of Ghent in 2012.

Research topics

• Medicine
• Computer Science
• Internal medicine
• Cardiology
• Intensive care medicine
• Pathology
• Virology

Selected publications

• Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction

  JACC Heart Failure · 2020 · 401 citations

  Senior authorCorresponding
  DOI

• Research Priorities for Heart Failure With Preserved Ejection Fraction

  Circulation · 2020 · 401 citations

  Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is rising in prevalence, is associated with high morbidity and mortality and is considered to be the greatest unmet need in cardiovascular medicine today because of a general lack of effective treatments. To address this challenging syndrome, the National Heart, Lung, and Blood Institute convened a working group made up of experts in HFpEF and novel research methodologies to discuss research gaps and to pr…

  DOI

• Thrombosis in <scp>COVID</scp>‐19

  American Journal of Hematology · 2020-08-28 · 322 citations

  reviewOpen accessSenior authorCorresponding

  Thrombotic complications are frequent in COVID-19 and contribute significantly to mortality and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be upregulated in COVID-19. These include immune-mediated thrombotic mechanisms, complement activation, macrophage activation syndrome, antiphospholipid antibody syndrome, hyperferritinemia, and renin-angiotensin system dysregulation. We highlight biomarkers within each pathway with potential prognostic value in COVID-19.…

  PublisherOA PDFDOI

• Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial

  The Lancet Respiratory Medicine · 2021 · 224 citations

  Senior authorCorresponding
  DOI

• Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

  Circulation Heart Failure · 2025-05-13 · 6 citations

  articleOpen access

  BACKGROUND: Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF) and is characterized by skeletal muscle (SkM) dysfunction with impaired oxidative capacity. To maintain oxidative capacity, the SkM secretes myokines such as musclin, which has been shown to potentiate NP (natriuretic peptide) signaling and induce PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1 alpha) signaling. We sought to investigate the role of musclin in SkM dysfunctio…

  PublisherDOI

Frequent coauthors

• Raymond R. Townsend

  578 shared

• Patrick Segers

  Ghent University Hospital

  557 shared

• Payman Zamani

  University of Pennsylvania Health System

  464 shared

• David R. Jacobs

  University of Minnesota

  303 shared

• Daniel Duprez

  University of Minnesota

  301 shared

• João A.C. Lima

  Johns Hopkins Medicine

  299 shared

• Richard A. Kronmal

  University of Washington

  294 shared

• Scott Lilly

  The Ohio State University

  273 shared

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