Payman Zamani
University of Pennsylvania · Rehabilitation Medicine
Active 2006–2026
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About
Payman Zamani, MD, MTR, is an Assistant Professor of Medicine in the Department of Cardiovascular Medicine at the Hospital of the University of Pennsylvania. He completed his undergraduate studies at Dartmouth College in 2001, earned his MD from Harvard Medical School in 2007, and obtained a Master of Science of Translational Research from the University of Pennsylvania in 2015. His clinical expertise focuses on heart failure with reduced ejection fraction and heart failure with preserved ejection fraction, as well as exercise physiology. His research interests include exercise and cardiovascular health, with a particular emphasis on innovative imaging methods, biological specimen analysis, and therapeutic interventions in heart failure. Dr. Zamani has contributed to numerous studies exploring the physiological and molecular mechanisms underlying heart failure and exercise tolerance, and his work involves investigating novel diagnostic and treatment strategies for cardiovascular diseases.
Research topics
- Medicine
- Internal medicine
- Cardiology
Selected publications
Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction
JACC Heart Failure · 2020 · 401 citations
Journal of the American College of Cardiology · 2020-03-01 · 214 citations
articleOpen accessHypertension · 2020-09-28 · 53 citations
articleOpen accessACE2 (angiotensin-converting enzyme 2) is a key component of the renin-angiotensin-aldosterone system. Yet, little is known about the clinical and biologic correlates of circulating ACE2 levels in humans. We assessed the clinical and proteomic correlates of plasma (soluble) ACE2 protein levels in human heart failure. We measured plasma ACE2 using a modified aptamer assay among PHFS (Penn Heart Failure Study) participants (n=2248). We performed an association study of ACE2 against ≈5000 other pla…
Circulation Heart Failure · 2024-02-01 · 24 citations
articleOpen accessBackground: NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels are variably elevated in heart failure with preserved ejection fraction (HFpEF), even in the presence of increased left ventricular filling pressures. NT-proBNP levels are prognostic in HFpEF and have been used as an inclusion criterion for several recent randomized clinical trials. However, the underlying biologic differences between HFpEF participants with high and low NT-proBNP levels remain to be fully understood. Metho…
Journal of the American Heart Association · 2024-08-29 · 18 citations
articleOpen accessBACKGROUND: The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach. METHODS AND RESULTS: We measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in thes…
Recent grants
HFpEF: more than just the heart - Why the mitochondria and capillaries matter
NIH · $699k · 2016–2020
Frequent coauthors
- 464 shared
Julio A. Chirinos
University of Pennsylvania
- 340 shared
Raymond R. Townsend
- 309 shared
Patrick Segers
Ghent University Hospital
- 275 shared
Scott Lilly
The Ohio State University
- 273 shared
David R. Jacobs
University of Minnesota
- 272 shared
Daniel Duprez
University of Minnesota
- 271 shared
Richard A. Kronmal
University of Washington
- 270 shared
João A.C. Lima
Johns Hopkins Medicine
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