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Seth Blackshaw

Seth Blackshaw

· Professor of Neuroscience

Johns Hopkins University · Neurosciences

Active 1994–2026

h-index108
Citations39.3k
Papers721304 last 5y
Funding$27.7M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

Faculty pageLab pageWebsite
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About

The Blackshaw lab aims to identify the molecular mechanisms that control the generation of the major cell types of the vertebrate retina and hypothalamus.

Research topics

  • Biology
  • Neuroscience
  • Medicine
  • Computer Science
  • Ophthalmology
  • Aesthetics
  • Art
  • Surgery
  • Cell biology
  • Genetics

Selected publications

  • Gene regulatory networks controlling vertebrate retinal regeneration

    Science · 2020 · 468 citations

    Senior authorCorresponding

    Injury induces retinal Müller glia of certain cold-blooded vertebrates, but not those of mammals, to regenerate neurons. To identify gene regulatory networks that reprogram Müller glia into progenitor cells, we profiled changes in gene expression and chromatin accessibility in Müller glia from zebrafish, chick, and mice in response to different stimuli. We identified evolutionarily conserved and species-specific gene networks controlling glial quiescence, reactivity, and neurogenesis. In zebrafi…

    DOI

  • Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

    Molecular Neurodegeneration · 2023 · 81 citations

    Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system's limited regenerative capacity. RGC repopulation is a promising therapeutic approach to reverse vision loss from optic neuropathies if the newly introduced neurons can reestablish functional retinal and thalamic circuits. In theory, RGCs might be repopulated through the transplantation of stem cell-derived neurons or via the induction of endo…

    PublisherOA PDFDOI

  • Atoh7-independent specification of retinal ganglion cell identity

    Science Advances · 2021 · 66 citations

    independent mechanisms for RGC specification.

    PublisherOA PDFDOI

  • Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep

    Science · 2025-06-19 · 21 citations

    article

    Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of thalamic nucleus reuniens (RE) neurons activated during sleep deprivation (SD) and required for sleep homeostasis. Optogenetic activation of RE neurons leads to an unusual phenotype: presleep behaviors (grooming and nest organizing) followed by prolonged, intense sleep that resembles RS. Inhibiting RE…

    PublisherDOI

  • Decoding gene networks controlling hypothalamic and prethalamic neuron development

    Cell Reports · 2025-06-01 · 13 citations

    articleOpen accessSenior author

    The hypothalamus and prethalamus regulate diverse physiological and behavioral processes, yet the gene regulatory networks guiding their development remain poorly defined. Using single-cell RNA and ATAC sequencing, we profile over 660,000 cells in the developing mouse hypothalamus and prethalamus between embryonic day 11 and postnatal day 8. This resource maps key transcriptional and chromatin dynamics underlying regionalization, neurogenesis, and neuronal subtype differentiation. We identify di…

    PublisherOA PDFDOI

Recent grants

Frequent coauthors

  • Jiang Qian

    Johns Hopkins Medicine

    279 shared

  • Dong Won Kim

    Aarhus University

    257 shared

  • Thanh Hoang

    University of Michigan–Ann Arbor

    167 shared

  • Heng Zhu

    Hubei University of Chinese Medicine

    151 shared

  • Clayton P. Santiago

    Johns Hopkins University

    139 shared

  • Solomon H. Snyder

    Johns Hopkins University

    131 shared

  • Lizhi Jiang

    Xiamen University

    115 shared

  • Brian S. Clark

    Washington University in St. Louis

    103 shared

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