Marilyn Albert

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial

The Lancet · 2023 · 403 citations

Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease

Annals of Neurology · 2021 · 134 citations

Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB breakdown and brain pathology, most commonly Alzheimer disease (AD) and vascular disease, is still poorly understood. The present study measured human BBB function in mild cognitive impairment (MCI) patients on 2 molecular scales, specifically BBB's permeability to water and albumin molecules. Methods Fifty‐five elderly participants were e…

Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment

Proceedings of the National Academy of Sciences · 2023 · 116 citations

= 359). In individuals with MCI (54% of whom were diagnosed with dementia within 10.9 y from MRI acquisition), BA is significantly better than CA in capturing dementia symptom severity, functional disability, and executive function. Profiles of sex dimorphism and lateralization in brain aging also map onto patterns of neuroanatomic change that reflect cognitive decline. Significant associations between BA and neurocognitive measures suggest that the proposed framework can map, systematically, th…

Lifetime risk and projected burden of dementia

Nature Medicine · 2025-01-13 · 100 citations

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Translational Psychiatry · 2021 · 65 citations

F-AV-1451 tau PET (baseline age 73.9 ± 7.7 years, 375 female) were stratified into five stages by a topographic PET staging scheme. Cognitive trajectories and clinical progression were compared across stages with or without further dichotomy of amyloid status, using linear mixed-effect models and Cox proportional hazard models. Significant cognitive decline was first observed in stage 1 when tau levels only increased in transentorhinal regions. Rates of cognitive decline and clinical progression…