Xinzhong Dong

About

Xinzhong Dong is a Professor of Neuroscience, Neurosurgery, and Dermatology at The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine. His profile is listed among former members of the department, indicating his previous affiliation and contributions to the field. The page provides information about his academic background, research focus, and professional trajectory, but does not include a detailed personal biography or specific descriptions of his research interests or key contributions.

Research topics

• Medicine
• Neuroscience
• Biology
• Immunology
• Cell biology
• Dermatology

Selected publications

• A basophil-neuronal axis promotes itch

  Cell · 2021 · 252 citations

  PublisherOA PDFDOI

• Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization

  Journal of Investigative Dermatology · 2021 · 92 citations

  DOI

• Astrocytes contribute to pain gating in the spinal cord

  Science Advances · 2021 · 85 citations

  Senior authorCorresponding

  neurons and pain inhibition by Aβ-fiber stimulation. Collectively, our study introduces astrocytes as an important component of pain gating by activation of Aβ-fibers, which thus exert nonneuronal control of pain.

  PublisherDOI

• Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

  Cell · 2025-03-24 · 37 citations

  articleOpen access
  PublisherOA PDFDOI

• A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis

  Cell · 2025-07-24 · 18 citations

  articleOpen accessSenior author

  The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response, yet the underlying mechanism remains unclear. Here, we show that the mast-cell-specific receptor Mrgprb2 regulates post-stroke brain inflammation from the meninges. Mrgprb2 causes meningeal mast cell degranulation after stroke, releasing immune mediators. This process recruits skull bone…

  PublisherOA PDFDOI

Recent grants

• Interdisciplinary Training in Biobehavioral Pain Research

  NIH · $3.6M · 2005–2026

• Functional Analysis of Mrgpr Family in itch sensation

  NIH · $2.9M · 2007–2029

• Characterization of a dendritic cell specific receptor critical for SJS

  NIH · $1.6M · 2018–2023

Frequent coauthors

• Yun Guan

  Johns Hopkins University

  289 shared

• Srinivasa N. Raja

  134 shared

• Qian Xu

  Johns Hopkins Medicine

  123 shared

• Shao-Qiu He

  Johns Hopkins Medicine

  106 shared

• Nathachit Limjunyawong

  Johns Hopkins University

  98 shared

• Fei Yang

  Jinan Central Hospital

  92 shared

• Vinod Tiwari

  85 shared

• Qian Huang

  Johns Hopkins Medicine

  81 shared

Labs

• Xinzhong Dong LabPI

  Not provided

Education

• PhD, Biological Chemistry

  University of California, Los Angeles

  1998

• BA

  College of the Holy Cross

  1992

Similar researchers at Johns Hopkins University

• Peter Campochiaroh-139
• Marilyn Alberth-125
• Seth Blackshawh-108