Russell Richardson

The exercise pressor reflex and chemoreflex interaction: cardiovascular implications for the exercising human

The Journal of Physiology · 2020 · 33 citations

KEY POINTS: Although the exercise pressor reflex (EPR) and the chemoreflex (CR) are recognized for their sympathoexcitatory effect, the cardiovascular implication of their interaction remains elusive. We quantified the individual and interactive cardiovascular consequences of these reflexes during exercise and revealed various modes of interaction. The EPR and hypoxia-induced CR interaction is hyper-additive for blood pressure and heart rate (responses during co-activation of the two reflexes ar…

Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction

Journal of Applied Physiology · 2020 · 32 citations

The current study identified, for the first time, an attenuation in exercising muscle blood flow during handgrip exercise in individuals with heart failure with preserved ejection fraction (HFpEF) compared with overweight individuals with hypertension, two of the most common comorbidities associated with HFpEF. These decrements in exercise hyperemia cannot be attributed to disease-related changes in central hemodynamics or endothelial function, providing additional evidence for disease-related v…

Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction

Journal of Applied Physiology · 2020 · 32 citations

We observed an approximately twofold improvement in conduit vessel function (brachial artery FMD), increased functional capacity (6MWT distance), and a reduction in inflammation (TNF-α and IL-18) following 3 mo of sacubitril-valsartan therapy. These findings provide important new information concerning the physiological mechanisms by which this new drug class provokes favorable changes in HFrEF pathophysiology.

Exercise training in COPD: muscle O₂transport plasticity

European Respiratory Journal · 2021 · 30 citations

transport.

Endurance exercise training changes the limitation on muscle VO2max${\dot{V}}_{{{\mathrm{O}}}_{\mathrm{2}}{\mathrm{max}}}$ in normoxia from the capacity to utilize O₂ to the capacity to transport O₂

The Journal of Physiology · 2023-12-04 · 19 citations

Abstract Maximal oxygen (O 2 ) uptake () is an important parameter with utility in health and disease. However, the relative importance of O 2 transport and utilization capacities in limiting muscle before and after endurance exercise training is not well understood. Therefore, the present study aimed to identify the mechanisms determining muscle pre‐ and post‐endurance exercise training in initially sedentary participants. In five initially sedentary young males, radial arterial and femoral ven…