Joel D. Trinity

About

Joel D. Trinity, PhD, is an Associate Professor in the Department of Internal Medicine and an Adjunct Assistant Professor in the Department of Nutrition and Integrative Physiology at the Spencer Fox Eccles School of Medicine. He joined the Utah Veterans' Research Laboratory (UVRL) in 2009 after completing his doctoral training at The University of Texas at Austin. Dr. Trinity's research utilizes an integrative approach that combines in-vivo and in-vitro techniques to examine the impact of age and disease, specifically hypertension, on vascular function and blood flow regulation. His current research interests include the complex interactions of neural control, oxidative stress, and vascular function in populations with chronic conditions such as COPD, heart failure, and hypertension. His graduate training focused on human performance, with dissertation work studying whole body physiology, particularly peripheral and central cardiovascular performance during exercise, and how factors like core and skin temperature influence cardiovascular responses. His research also explores physiological adaptations during intense exercise and fatigue, as well as vascular and cardiovascular responses in various disease states.

Research topics

• Medicine
• Cardiology
• Internal medicine
• Virology
• Pathology

Selected publications

• Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

  JAMA · 2023 · 831 citations

  Importance: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. Objective: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination stat…

  PublisherOA PDFDOI

• Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction

  Journal of Applied Physiology · 2020 · 32 citations

  The current study identified, for the first time, an attenuation in exercising muscle blood flow during handgrip exercise in individuals with heart failure with preserved ejection fraction (HFpEF) compared with overweight individuals with hypertension, two of the most common comorbidities associated with HFpEF. These decrements in exercise hyperemia cannot be attributed to disease-related changes in central hemodynamics or endothelial function, providing additional evidence for disease-related v…

  DOI

• Activating P2Y1 receptors improves function in arteries with repressed autophagy

  Cardiovascular Research · 2022-04-14 · 25 citations

  articleOpen access

  AIM: The importance of endothelial cell (EC) autophagy to vascular homeostasis in the context of health and disease is evolving. Earlier, we reported that intact EC autophagy is requisite to maintain shear-stress-induced nitric oxide (NO) generation via glycolysis-dependent purinergic signalling to endothelial NO synthase (eNOS). Here, we illustrate the translational and functional significance of these findings. METHODS AND RESULTS: First, we assessed translational relevance using older male hu…

  PublisherOA PDFDOI

• Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial

  Experimental Gerontology · 2022-04-09 · 13 citations

  articleOpen access
  PublisherOA PDFDOI

• Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort

  Nature Communications · 2025-11-17 · 8 citations

  articleOpen access

  Longitudinal trajectories of Long COVID remain ill-defined, yet are critically needed to advance clinical trials, patient care, and public health initiatives for millions of individuals with this condition. Long COVID trajectories were determined prospectively among 3,659 participants (69% female; 99.6% Omicron era) in the National Institutes of Health Researching COVID to Enhance Recovery (RECOVER) Adult Cohort. Finite mixture modeling was used to identify distinct longitudinal profiles based o…

  PublisherOA PDFDOI

Recent grants

• Understanding the Exercise-Hypertension Paradox: Implication for Rehabilitation

  NIH · 2014–2019

• Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during Disuse

  NIH · $2.9M · 2019–2026

• Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during Disuse

  NIH · 2019–2023

Frequent coauthors

• Russell S. Richardson

  University of Utah

  474 shared

• Gwenaël Layec

  187 shared

• D. Walter Wray

  University of Utah

  134 shared

• Jayson R. Gifford

  127 shared

• Stephen J. Ives

  Skidmore College

  120 shared

• Corey R. Hart

  Mayo Clinic

  115 shared

• Ryan M. Broxterman

  University of Utah

  113 shared

• Melissa A. H. Witman

  University of Delaware

  92 shared

Labs

• UVRL (University of Utah Vascular Research Laboratory)PI

Education

• Ph.D.

  The University of Texas at Austin

Similar researchers at University of Utah

• Anthony J. Donatoh-73
• Mark A. Supianoh-54