Ryan M. Broxterman

About

Dr. Ryan M. Broxterman, Ph.D., is an Assistant Professor of Internal Medicine in the Division of Geriatrics and an Adjunct Assistant Professor in the Department of Nutrition & Integrative Physiology at the University of Utah. He is also a Research Health Scientist at the Salt Lake City Veterans Affairs Geriatric Research, Education, and Clinical Center. His research broadly focuses on the integration of vascular, metabolic, and neuromuscular function as determinants of health and physical function. This includes assessing vascular function, oxygen transport and utilization, exercise tolerance, and skeletal muscle bioenergetics in health and disease. Dr. Broxterman has published over 65 peer-reviewed papers in various scientific journals and maintains an extramurally-funded research program. His work aims to understand the physiological mechanisms underlying exercise capacity, vascular health, and aging, with particular attention to how these systems interact in different health conditions and in response to interventions such as exercise and dietary supplementation.

Research topics

• Medicine
• Cardiology
• Internal medicine
• Chemistry
• Endocrinology
• Anesthesia
• Biochemistry

Selected publications

• On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A ³¹P‐MRS study

  The Journal of Physiology · 2022 · 83 citations

  Abstract Intramuscular hydrogen ion (H + ) and inorganic phosphate (Pi) concentrations were dissociated during exercise to challenge their relationships with peripheral and central fatigue in vivo . Ten recreationally active, healthy men (27 ± 5 years; 180 ± 4 cm; 76 ± 10 kg) performed two consecutive intermittent isometric single‐leg knee‐extensor trials (60 maximal voluntary contractions; 3 s contraction, 2 s relaxation) interspersed with 5 min of rest. Phosphorus magnetic resonance spectrosco…

  PublisherOA PDFDOI

• Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction

  Journal of Applied Physiology · 2020 · 32 citations

  The current study identified, for the first time, an attenuation in exercising muscle blood flow during handgrip exercise in individuals with heart failure with preserved ejection fraction (HFpEF) compared with overweight individuals with hypertension, two of the most common comorbidities associated with HFpEF. These decrements in exercise hyperemia cannot be attributed to disease-related changes in central hemodynamics or endothelial function, providing additional evidence for disease-related v…

  DOI

• Exercise training in COPD: muscle O₂transport plasticity

  European Respiratory Journal · 2021 · 30 citations

  1st authorCorresponding

  transport.

  DOI

• Endurance exercise training changes the limitation on muscle VO2max${\dot{V}}_{{{\mathrm{O}}}_{\mathrm{2}}{\mathrm{max}}}$ in normoxia from the capacity to utilize O₂ to the capacity to transport O₂

  The Journal of Physiology · 2023-12-04 · 19 citations

  articleOpen access1st authorCorresponding

  Abstract Maximal oxygen (O 2 ) uptake () is an important parameter with utility in health and disease. However, the relative importance of O 2 transport and utilization capacities in limiting muscle before and after endurance exercise training is not well understood. Therefore, the present study aimed to identify the mechanisms determining muscle pre‐ and post‐endurance exercise training in initially sedentary participants. In five initially sedentary young males, radial arterial and femoral ven…

  PublisherOA PDFDOI

• α‐Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction

  The Journal of Physiology · 2024-06-06 · 9 citations

  articleOpen access

  Abstract Heart failure with preserved ejection fraction (HFpEF) has been characterized by lower blood flow to exercising limbs and lower peak oxygen utilization (), possibly associated with disease‐related changes in sympathetic (α‐adrenergic) signaling. Thus, in seven patients with HFpEF (70 ± 6 years, 3 female/4 male) and seven controls (CON) (66 ± 3 years, 3 female/4 male), we examined changes (%Δ) in leg blood flow (LBF, Doppler ultrasound) and leg to intra‐arterial infusion of phentolamine…

  PublisherOA PDFDOI

Frequent coauthors

• Russell S. Richardson

  University of Utah

  227 shared

• Joel D. Trinity

  University of Utah

  113 shared

• D. Walter Wray

  University of Utah

  74 shared

• Jesse C. Craig

  University of Utah

  72 shared

• Catherine L. Jarrett

  Geriatric Research Education and Clinical Center

  66 shared

• Jayson R. Gifford

  62 shared

• Stephen M. Ratchford

  University of Utah

  59 shared

• Thomas J. Barstow

  Kansas State University

  53 shared

Labs

• Utah Vascular Research Laboratory (UVRL)PI

Education

• Ph.D.

  University of Utah

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• Mark A. Supianoh-54