Roger D. Kamm

About

Professor Roger D. Kamm is the Cecil H. Green Distinguished Professor at MIT in the Department of Biological Engineering. His research focuses on elucidating the fundamental nature of how cells sense and respond to mechanical stimuli, and using this knowledge to understand cell population behaviors such as the emergence of form and function. His work employs both experimental and computational approaches, encouraging the constant interplay between the two for model validation, direct measurement of critical parameters, and the development of new hypotheses for testing through experiments. The Kamm research group works across five broad areas: Biological Machines and Microfluidics, Angiogenesis and Vasculogenesis, Neurological Diseases, Cancer, and Simulation and Modeling. His lab aims to employ the principles revealed by these studies to seek new treatments for neurological diseases and cancer, as well as to develop tissue constructs for drug and toxicity screening. Professor Kamm began his career at Northwestern University with a degree in Mechanical Engineering and earned both a Master’s and a PhD in Mechanical Engineering at MIT. Since 1978, he has been a professor at MIT and was one of the founding members of the Biological Engineering Department when it was created in 1998.

Research topics

• Computer Science
• Biology
• Cell biology
• Biotechnology
• Chemistry
• Biophysics
• Medicine
• Pathology
• Genetics
• Computational biology

Selected publications

• The bioprinting roadmap

  Biofabrication · 2020 · 397 citations

  This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges, as well as envisioned advances in science and technology, to address the challenges to the young and evolving technique. The topics covered in this roadmap encompass the broad spectrum of bioprinting; from cell expansion and novel bioink development to cell/stem cell printing, from organoid-based tissue organization to bioprinting of human…

  DOI

• Rethinking organoid technology through bioengineering

  Nature Materials · 2020 · 315 citations

  DOI

• Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature

  Lab on a Chip · 2021 · 283 citations

  Senior authorCorresponding

  Possible strategy to integrate pre-vascularized organoid and <italic>in vitro</italic> capillary bed on a microfluidic based platform, aiming for establishing perfused vasculature throughout organoids <italic>in vitro</italic>.

  DOI

• Tumor cell nuclei soften during transendothelial migration

  Journal of Biomechanics · 2021 · 78 citations

  DOI

• Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application

  Lab on a Chip · 2020 · 42 citations

  Currently used animal and cellular models for pulmonary arterial hypertension (PAH) only partially recapitulate its pathophysiology in humans and are thus inadequate in reproducing the hallmarks of the disease, inconsistent in portraying the sex-disparity, and unyielding to combinatorial study designs. Here we sought to deploy the ingenuity of microengineering in developing and validating a tissue chip model for human PAH. We designed and fabricated a microfluidic device to emulate the luminal,…

  DOI

Recent grants

• NIH Grant U01CA20217701

  NIH · $672k · 2020

• NIH Grant T32EB006348

  NIH · $1.6M · 2012

• NIH Grant R01EY005503

  NIH · $1.4M · 1992

Frequent coauthors

• Andrea Pavesi

  Agency for Science, Technology and Research

  86 shared

• Seok Chung

  Korea Institute of Science and Technology

  84 shared

• Giulia Adriani

  National University of Singapore

  79 shared

• Mohammad R. K. Mofrad

  University of California, Berkeley

  74 shared

• Sharon Wei Ling Lee

  Massachusetts Institute of Technology

  66 shared

• Richard Lee

  65 shared

• Ioannis K. Zervantonakis

  UPMC Hillman Cancer Center

  61 shared

• H. Harry Asada

  Massachusetts Institute of Technology

  57 shared

Education

• Ph.D., Biological Engineering

  Massachusetts Institute of Technology

  1984

• B.S., Mechanical Engineering

  University of California, Berkeley

  1979

Similar researchers at Massachusetts Institute of Technology

• James J. Collinsh-232
• James G. Foxh-114
• Jongyoon Hanh-88