Jongyoon Han

About

Professor Jongyoon Han is a faculty member at the Massachusetts Institute of Technology (MIT), serving as a Professor of Electrical Engineering and a Professor of Biological Engineering. He is the principal investigator of the Micro/Nanofluidic BioMEMS Group within the Research Laboratory of Electronics (RLE) at MIT. His research focuses on developing new tools and technologies for biomolecule separation and analysis using advanced microfluidics and nanofluidics. His work critically depends on understanding biological systems through the analysis of biomolecules and sub-cellular components, with advances in biology often coinciding with breakthroughs in the ability to separate and identify target biomolecules within complex intracellular environments. Professor Han received his B.S. and M.S. degrees from the Department of Physics at Seoul National University in Korea and earned his PhD from the School of Applied and Engineering Physics at Cornell University. Prior to joining the Department of Biological Engineering at MIT, he was a research scientist at Sandia National Laboratories, where he studied protein microfluidic separation systems. His research contributions include developing innovative tools for biomolecule analysis, which are essential for advancing biological understanding and medical applications.

Research topics

• Computer Science
• Physics
• Materials science
• Nanotechnology
• Optics
• Acoustics
• Engineering
• Geology
• Mechanical engineering
• Optoelectronics

Selected publications

• Fully-automated and field-deployable blood leukocyte separation platform using multi-dimensional double spiral (MDDS) inertial microfluidics

  Lab on a Chip · 2020 · 74 citations

  Senior authorCorresponding

  A fully-automated and portable leukocyte separation platform was developed based on a new type of inertial microfluidic device, multi-dimensional double spiral (MDDS) device, as an alternative to centrifugation. By combining key innovations in inertial microfluidic device designs and check-valve-based recirculation processes, highly purified and concentrated WBCs (up to >99.99% RBC removal, ∼80% WBC recovery, >85% WBC purity, and ∼12-fold concentrated WBCs compared to the input sample) were achi…

  DOI

• Massively Multiplexed Submicron Particle Patterning in Acoustically Driven Oscillating Nanocavities

  Small · 2020 · 52 citations

  Nanoacoustic fields are a promising method for particle actuation at the nanoscale, though THz frequencies are typically required to create nanoscale wavelengths. In this work, the generation of robust nanoscale force gradients is demonstrated using MHz driving frequencies via acoustic-structure interactions. A structured elastic layer at the interface between a microfluidic channel and a traveling surface acoustic wave (SAW) device results in submicron acoustic traps, each of which can trap ind…

  DOI

• Diffraction-based acoustic manipulation in microchannels enables continuous particle and bacteria focusing

  Lab on a Chip · 2020 · 45 citations

  Acoustic fields have shown wide utility for micromanipulation, though their implementation in microfluidic devices often requires accurate alignment or highly precise channel dimensions, including in typical standing surface acoustic wave (SSAW) devices and resonant channels. In this work we investigate an approach that permits continuous microscale focusing based on diffractive acoustics, a phenomenon where a time-averaged spatially varying acoustic pressure landscape is produced by bounding a…

  DOI

• Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair

  Stem Cell Research & Therapy · 2024-09-16 · 11 citations

  articleOpen access

  Abstract Background Articular cartilage degeneration can result from injury, age, or arthritis, causing significant joint pain and disability without surgical intervention. Currently, the only FDA cell-based therapy for articular cartilage injury is Autologous Chondrocyte Implantation (ACI); however, this procedure is costly, time-intensive, and requires multiple treatments. Mesenchymal stromal cells (MSCs) are an attractive alternative autologous therapy due to their availability and ability to…

  PublisherOA PDFDOI

• Comparative Analysis of Serum and Serum-Free Medium Cultured Mesenchymal Stromal Cells for Cartilage Repair

  International Journal of Molecular Sciences · 2024-10-02 · 9 citations

  articleOpen accessSenior authorCorresponding

  Mesenchymal stromal cells (MSCs) are promising candidates for cartilage repair therapy due to their self-renewal, chondrogenic, and immunomodulatory capacities. It is widely recognized that a shift from fetal bovine serum (FBS)-containing medium toward a fully chemically defined serum-free (SF) medium would be necessary for clinical applications of MSCs to eliminate issues such as xeno-contamination and batch-to-batch variation. However, there is a notable gap in the literature regarding the eva…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01AI041637

  NIH · $5.1M · 2014

• CAREER: Nanofluidic Molecular Filters

  NSF · $400k · 2004–2009

• Novel Process Analytic Technology for Continuous Bioprocessses

  NIH · $4.8M · 2019–2023

Frequent coauthors

• Chwee Teck Lim

  National University of Singapore

  151 shared

• Han Wei Hou

  90 shared

• Ali Asgar S. Bhagat

  National University of Singapore

  70 shared

• Yong‐Ak Song

  58 shared

• Zirui Li

  57 shared

• Leon D. Li

  Massachusetts Institute of Technology

  54 shared

• Hiong Yap Gan

  Singapore Institute of Technology

  43 shared

• Zheng Yang

  43 shared

Education

• Ph.D., Biological Engineering

  Massachusetts Institute of Technology

  2006

• M.S., Biological Engineering

  Massachusetts Institute of Technology

  2002

• B.S., Bioengineering

  University of California, San Diego

  2000

Similar researchers at Massachusetts Institute of Technology

• James J. Collinsh-232
• Roger D. Kammh-129
• James G. Foxh-114