James G. Fox

About

James G. Fox, PhD, is a Professor of Biological Engineering at MIT. His research focuses on infectious diseases of the gastrointestinal tract, particularly the pathogenesis of Campylobacter spp. and Helicobacter spp. infections in humans and animals. His laboratory has developed models such as the ferret for campylobacter and helicobacter-associated diseases, as well as the first rodent model to study helicobacter-associated gastric disease, including gastric cancer. Dr. Fox is recognized as an international authority on the epidemiology and pathogenesis of enterohepatic helicobacters, having identified, named, and described many diseases attributed to various Helicobacter species, including their links to hepatitis, liver tumors, inflammatory bowel disease, and colon cancer. His work has also elucidated the role of Helicobacter spp. in the development of cholesterol gallstones in mice, connecting these findings to human populations at high risk for gallbladder cancer. With over 35 years of experience, Dr. Fox has contributed significantly to understanding zoonotic diseases and biosafety issues related to in vivo models. He holds a Master of Science in Medical Microbiology from Stanford University and a Doctor in Veterinary Medicine from Colorado State University. He has served as the founding Director of the Division of Comparative Medicine, and has held leadership roles including past president of the American College of Laboratory Animal Medicine, the Massachusetts…

Research topics

• Biology
• Immunology
• Medicine
• Internal medicine
• Cancer research
• Cell biology
• Neuroscience
• Genetics
• Psychology
• Microbiology

Selected publications

• ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

  Nature · 2022 · 272 citations

  PublisherOA PDFDOI

• PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice

  Gastroenterology · 2020 · 144 citations

  DOI

• Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

  Cell stem cell · 2021 · 137 citations

  DOI

• Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research

  Proceedings of the National Academy of Sciences · 2020 · 122 citations

  The recently developed new genome-editing technologies, such as the CRISPR/Cas system, have opened the door for generating genetically modified nonhuman primate (NHP) models for basic neuroscience and brain disorders research. The complex circuit formation and experience-dependent refinement of the human brain are very difficult to model in vitro, and thus require use of in vivo whole-animal models. For many neurodevelopmental and psychiatric disorders, abnormal circuit formation and refinement…

  PublisherOA PDFDOI

• Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23

  Cell Metabolism · 2021 · 97 citations

  PublisherOA PDFDOI

Recent grants

• NIH Grant T32OD01097826

  NIH · $322k · 2018

• NIH Grant P01CA028842

  NIH · $27.7M · 2023

• NIH Grant T32OD010978

  NIH · $1.9M · 2018

Frequent coauthors

• Timothy C. Wang

  Columbia University

  227 shared

• Sureshkumar Muthupalani

  160 shared

• Arlin B. Rogers

  Alnylam Pharmaceuticals (United States)

  148 shared

• Zhongming Ge

  134 shared

• Mark T. Whary

  Massachusetts Institute of Technology

  117 shared

• Nancy S. Taylor

  105 shared

• Zeli Shen

  Massachusetts Institute of Technology

  95 shared

• Shigeo Takaishi

  Kyoto University

  80 shared

Awards & honors

• Fellow of the Infectious Disease Society of America
• Elected to the Institute of Medicine of the National Academy…

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