Muhammad G. Saleh

About

Muhammad G. Saleh, PhD, is an Assistant Professor of Radiology at the University of Pennsylvania's Perelman School of Medicine and a Senior Principal Scientist in the Radiology Research Group at the Children’s Hospital of Philadelphia. His research focuses on neurometabolic differentiation, brain chemistry, and neuroimaging techniques such as magnetic resonance spectroscopy. Dr. Saleh has contributed to understanding brain metabolism in various conditions, including hypersomnolence, HIV, autism, and the effects of aging on brain metabolites. His work involves advanced neuroimaging methods to investigate neural excitation-inhibition balance, brain susceptibility, and neurometabolite changes during early infancy, with a goal to improve diagnostic and therapeutic strategies in neurological and psychiatric disorders.

Research topics

• Computer Science
• Nuclear medicine
• Medicine
• Artificial Intelligence
• Physics
• Nuclear magnetic resonance
• Internal medicine
• Radiology

Selected publications

• Osprey: Open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data

  Journal of Neuroscience Methods · 2020-06-27 · 255 citations

  articleOpen access
  PublisherOA PDFDOI

• <scp>GABA</scp> and glutamate measurements in temporal cortex of autistic children

  Autism Research · 2024-11-11 · 8 citations

  articleOpen access1st authorCorresponding

  Autism spectrum disorder (ASD) is a neurodevelopmental disorder and presents with challenges in social communication. A hypothesized underlying contributing mechanism is the imbalance in excitation and inhibition (E/I), partly influenced by the levels of excitatory neurotransmitter glutamate (Glu) and inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the brain. Although many have reported the levels of GABA and Glu in the brain, only a few reports address the temporal cortex and then onl…

  PublisherOA PDFDOI

• Glutamate measurements using edited MRS

  Magnetic Resonance in Medicine · 2023-12-03 · 7 citations

  articleOpen access1st authorCorresponding

  Abstract Purpose To demonstrate J‐ difference coediting of glutamate using Hadamard encoding and reconstruction of Mescher‐Garwood‐edited spectroscopy (HERMES). Methods Density‐matrix simulations of HERMES (TE 80 ms) and 1D J ‐resolved (TE 31–229 ms) of glutamate (Glu), glutamine (Gln), γ‐aminobutyric acid (GABA), and glutathione (GSH) were performed. HERMES comprised four sub‐experiments with editing pulses applied as follows: (A) 1.9/4.56 ppm simultaneously (ON GABA /ON GSH ); (B) 1.9 ppm only…

  PublisherOA PDFDOI

• Simultaneous Measurement of <scp>GABA</scp>, Glutathione, and Glutamate–Glutamine in the Thalamus using Edited <scp>MR</scp> Spectroscopy: Feasibility and Applications in Traumatic Brain Injury

  Journal of Magnetic Resonance Imaging · 2024-02-16 · 3 citations

  articleOpen access

  BACKGROUND: MR spectroscopy (MRS) is a noninvasive tool for evaluating biochemical alterations, such as glutamate (Glu)/gamma-aminobutyric acid (GABA) imbalance and depletion of antioxidative glutathione (GSH) after traumatic brain injury (TBI). Thalamus, a critical and vulnerable region post-TBI, is challenging for MRS acquisitions, necessitating optimization to simultaneously measure GABA/Glu and GSH. PURPOSE: To assess the feasibility and optimize acquisition and processing approaches for sim…

  PublisherOA PDFDOI

• GABA (gamma-aminobutyric acid) levels in dorsal anterior cingulate cortex are negatively associated with food motivation in a pediatric sample

  Scientific Reports · 2024-10-22 · 1 citations

  articleOpen access

  Food motivation varies between individuals, affecting body weight and risk for eating disorders. Prior neuroimaging studies in youth and adults have revealed functional and structural alterations in the anterior cingulate cortex [ACC] in those with obesity and disordered eating but have not investigated their neurochemical underpinnings. In a sample of 37 children aged 4 to 13 years old, we used Magnetic Resonance Spectroscopy [MRS] to assess levels of γ-aminobutyric acid [GABA] - the major inhi…

  PublisherOA PDFDOI

Recent grants

• Neurometabolic profile of tobacco smoking in HIV-infected Individuals

  NIH · $747k · 2021–2026

• Neurometabolic profile of tobacco smoking in HIV-infected Individuals

  NIH · $347k · 2021–2023

Frequent coauthors

• Richard A.E. Edden

  121 shared

• Mark E. Mikkelsen

  Weill Cornell Medicine

  81 shared

• Georg Oeltzschner

  71 shared

• Kimberly L. Chan

  The University of Texas Southwestern Medical Center

  70 shared

• Michael Dacko

  University Medical Center Freiburg

  61 shared

• Jamie Near

  University of Toronto

  60 shared

• Helge J. Zöllner

  Johns Hopkins Medicine

  58 shared

• Thomas Lange

  University Medical Center Freiburg

  55 shared

Labs

• Muhammad G. Saleh LaboratoryPI

Education

• PhD in Biomedical Engineering, Human Biology

  University of Cape Town

  2016

Similar researchers at University of Pennsylvania

• John Q. Trojanowskih-296
• Craig B. Thompsonh-277
• Daniel J Raderh-236