Mark E. Mikkelsen

Society of Critical Care Medicine’s International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness

Critical Care Medicine · 2020-09-18 · 428 citations

BACKGROUND: After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when remain unclear. OBJECTIVES: Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to screening for postdischarge impairments. PARTICIPANTS: Thirty-one international experts in risk-stratification and assessmen…

Locally Informed Simulation to Predict Hospital Capacity Needs During the COVID-19 Pandemic

Annals of Internal Medicine · 2020-04-07 · 319 citations

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic challenges hospital leaders to make time-sensitive, critical decisions about clinical operations and resource allocations. OBJECTIVE: To estimate the timing of surges in clinical demand and the best- and worst-case scenarios of local COVID-19-induced strain on hospital capacity, and thus inform clinical operations and staffing demands and identify when hospital capacity would be saturated. DESIGN: Monte Carlo simulation instantiation o…

Osprey: Open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data

Journal of Neuroscience Methods · 2020-06-27 · 255 citations

A Research Agenda to Mitigate Racial and Ethnic Disparities in U.S. Critical Care Medicine: An Official American Thoracic Society Research Statement

American Journal of Respiratory and Critical Care Medicine · 2025-12-01 · 1 citations

Abstract Background Racial and ethnic disparities exist in critical illness outcomes in the United States. Objectives To identify research priorities for reducing disparities in U.S. critical illness outcomes. Methods A 22-member multidisciplinary committee participated in virtual workshops to appraise the literature and discuss opportunities for structural changes to reduce disparities in critical illness outcomes. The co-chairs conducted content analysis of workshop recordings to identify rese…

Reproducibility of HERMES-measured GABA+ and GSH in the Mesial Temporal Lobe

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 2025-09-16

Motivation: Quantification of measurement reproducibility of in vivo MRS experiments enables the planning of future studies. Evidence of reproducibility of simultaneous measurement of GABA and GSH using Hadamard-encoded spectral editing (i.e., HERMES) in challenging brain regions for MRS, such as the mesial temporal lobe (MTL), is needed. Goal(s): Determine the reproducibility of HERMES-sLASER in the MTL. Approach: Two MTL HERMES scans were acquired in 15 participants, with participants repositi…