Michael O. Harhay

About

Michael O. Harhay, PhD, is an Associate Professor of Epidemiology in Biostatistics and Epidemiology at the Perelman School of Medicine, University of Pennsylvania. He serves as a Scientific Advisor for Statistical Evaluation at the Penn Medicine Nudge Unit within the Center for Health Care Transformation and Innovation, and is the Founding Director of the Center for Clinical Trials Innovation at Penn Medicine. His research expertise includes clinical epidemiology, medical statistics, and evidence synthesis. Dr. Harhay has a comprehensive educational background with degrees in Neuroscience and Philosophy from Muhlenberg College, and multiple advanced degrees from the University of Pennsylvania, including a PhD in Epidemiology. His work involves applying Bayesian statistics and other advanced statistical methods to clinical research, with a focus on improving trial design, analysis, and interpretation in critical care and other medical fields.

Research topics

• Medicine
• Internal medicine
• Intensive care medicine
• Data Mining
• Computer Science
• Nursing
• Virology
• Emergency medicine
• Family medicine
• Mathematics

Selected publications

• Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal

  BMJ · 2020-04-07 · 3227 citations

  reviewOpen access

  OBJECTIVE: To review and appraise the validity and usefulness of published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with covid-19, and for detecting people in the general population at increased risk of covid-19 infection or being admitted to hospital with the disease. DESIGN: Living systematic review and critical appraisal by the COVID-PRECISE (Precise Risk Estimation to optimise…

  PublisherOA PDFDOI

• A minimal common outcome measure set for COVID-19 clinical research

  The Lancet Infectious Diseases · 2020 · 1782 citations

  DOI

• Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

  The Lancet Respiratory Medicine · 2020-10-16 · 907 citations

  reviewOpen access
  PublisherOA PDFDOI

• Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry

  Critical Care Medicine · 2021 · 140 citations

  OBJECTIVES: To describe the outcomes of hospitalized patients in a multicenter, international coronavirus disease 2019 registry. DESIGN: Cross-sectional observational study including coronavirus disease 2019 patients hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection between February 15, 2020, and November 30, 2020, according to age and type of organ support therapies. SETTING: About 168 hospitals in 16 countries within the Society of Critical Care M…

  DOI

• What Matters to Patients and Their Families During and After Critical Illness: A Qualitative Study

  American Journal of Critical Care · 2021 · 70 citations

  BACKGROUND: Despite increased emphasis on providing higher-quality patient- and family-centered care in the intensive care unit (ICU), there are no widely accepted definitions of such care in the ICU. OBJECTIVES: To determine (1) aspects of care that patients and families valued during their ICU encounter, (2) outcomes that patients and families prioritized after hospital discharge, and (3) outcomes perceived as equivalent to or worse than death. METHODS: Semistructured interviews (n = 49) of fo…

  DOI

Recent grants

• Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failure

  NIH · $747k · 2018–2023

• Advancing the design, analysis, and interpretation of acute respiratory distress syndrome trials using modern statistical tools

  NIH · $2.2M · 2023–2028

• NIH Grant F31HL127947

  NIH · $71k · 2017

Frequent coauthors

• Scott D. Halpern

  University of Pennsylvania

  105 shared

• Mark E. Mikkelsen

  Weill Cornell Medicine

  36 shared

• Meera N. Harhay

  Drexel University

  28 shared

• Dylan S. Small

  28 shared

• Ernest K. Manders

  University of Pittsburgh

  25 shared

• Ewan C. Goligher

  25 shared

• Harry S. Nayar

  25 shared

• Naveen K. Ahuja

  Rutgers, The State University of New Jersey

  25 shared

Labs

• Michael O. Harhay LabPI

Education

• PhD, Biostatistics, Epidemiology and Informatics

  University of Pennsylvania

  2016

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