About

Ling Qin, Ph.D., is a Professor of Orthopaedic Surgery at the University of Pennsylvania's Perelman School of Medicine. He is a member of the Penn Center for Musculoskeletal Disorders, the Abramson Cancer Center, the Institute for Diabetes, Obesity, and Metabolism (IDOM), and the Diabetes Research Center (DRC). Dr. Qin's research focuses on the cellular and molecular mechanisms underlying skeletal development, homeostasis, aging, and diseases such as osteoporosis and osteoarthritis. His laboratory utilizes advanced techniques including single-cell transcriptomics, 3D fluorescent imaging, and genetically modified animal models to identify mesenchymal stem and progenitor cells across various musculoskeletal sites and to investigate their functions under normal and disease conditions. His ongoing projects include delineating mesenchymal stem cells in bone marrow, periosteum, joint, and muscle, studying a novel adipose cell type in bone marrow, understanding radiation-induced osteoporosis and fracture healing, and exploring therapeutic targets for osteoarthritis and meniscus injury. Dr. Qin has made significant contributions to understanding skeletal cell functions and aims to translate these fundamental insights into clinical applications.

Research topics

• Pathology
• Medicine
• Anatomy
• Internal medicine
• Intensive care medicine
• Materials science
• Composite material
• Biomedical engineering
• Biology
• Physical therapy
• Surgery
• Cell biology

Selected publications

• 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model

  Biomaterials · 2021 · 175 citations

  • Biomedical engineering
  • Materials science
  • Cell biology
  DOI

• Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)

  Journal of Orthopaedic Translation · 2020 · 436 citations

  Senior authorCorresponding
  • Medicine
  • Intensive care medicine
  • Physical therapy

  Osteonecrosis of the femoral head (ONFH) is a common and refractory disease in orthopaedic clinics. The number of patients with ONFH is increasing worldwide every year. There are an estimated 8.12 million patients with nontraumatic osteonecrosis in China alone. Treatment of nontraumatic osteonecrosis has always been a clinical challenge for orthopaedic surgeons. To further standardize diagnosis and treatment of ONFH, these guidelines provide not only basic diagnosis, treatment, and evaluation systems for ONFH but also expert advice and standards in many aspects, including epidemiology, aetiology, diagnostic criteria, pathological staging, prevention and treatment options, and postoperative rehabilitation. The aetiological factors of ONFH can currently be divided into two major categories: traumatic and nontraumatic; however, the specific pathological mechanism of ONFH is not completely clear. Currently, the staging system of ONFH formulated by the Association Research Circulation Osseous is widely used in clinical practice. Based on the changes in the intraosseous blood supply at different stages, the corresponding nonsurgical and surgical treatments are recommended, and when there are risk factors for possible ONFH, certain preventive measures to avoid the occurrence of osteonecrosis are recommended. These guidelines provide brief classification criteria and treatment regimen for osteonecrosis. Specification of the aetiology, treatment plan based on comprehensive consideration of the different stages of osteonecrosis, hip function, age, and occupation of the patients are important steps in diagnosis and developing treatment strategies. TRANSLATIONAL POTENTIAL OF THIS ARTICLE: New advances in the epidemiology, etiology, pathophysiology, imaging, diagnosis and treatment of ONFH have been renewed in this revision. This guideline can be used for reference by orthopedic professionals and researchers, and for standardized diagnosis and treatment management under the clinical guidance, which is conducive to the prevention, treatment and further research of ONFH, improving the diagnosis and treatment level, making patients' symptoms under good control, and improving their quality of life.

  DOI

Frequent coauthors

• Xinluan Wang

  538 shared

• Yuxiao Lai

  Chinese Academy of Sciences

  262 shared

• Ge Zhang

  Hong Kong Baptist University

  162 shared

• James F. Griffith

  155 shared

• Jack C. Y. Cheng

  153 shared

• Wing‐Hoi Cheung

  Chinese University of Hong Kong

  142 shared

• Xinhui Xie

  139 shared

• Kwok‐Sui Leung

  Chinese University of Hong Kong

  133 shared

Labs

• Qin LabPI

Education

• Professor, Orthopaedics and Traumatology

  The Chinese University of Hong Kong

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