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John Chang

· MD

University of California, San Diego · Gastroenterology

Active 1998–2025

h-index60
Citations14.8k
Papers20470 last 5y
Funding$32.9M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Dr. John Chang studies the cellular and molecular mechanisms underlying T lymphocyte fate specification. His research focuses on understanding how activated T lymphocytes give rise to differentially fated progeny, addressing a central problem faced by multi-cellular organisms: the need for rare progenitor cells to continually produce terminally differentiated cells while preserving a self-renewing lineage. In the mammalian immune system, this challenge is exemplified by T lymphocytes, which must simultaneously differentiate and regenerate. Dr. Chang's work aims to elucidate the molecular mechanisms that enable this balance in T lymphocyte populations. He has been recognized with several prestigious awards, including the HHMI Physician-Scientist Early Career Award, the NIH Director's New Innovator Award, and the AGA-GRG Young Investigator Award in Basic Science. Additionally, Dr. Chang has been elected to the American Society for Clinical Investigation (ASCI) and is supported by grants from the National Institutes of Health and the Kenneth Rainin Foundation.

Research topics

  • Biology
  • Genetics
  • Immunology
  • Medicine
  • Bioinformatics
  • Pathology
  • Neuroscience
  • Biochemistry
  • Computational biology
  • Chemistry

Selected publications

Recent grants

Frequent coauthors

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