Ananda Goldrath

About

Professor Ananda Goldrath's research focuses on the mechanisms underlying immunological memory, particularly how memory T cells are generated and maintained. His lab investigates the signaling pathways and molecular events that regulate the survival and differentiation of T cells as they respond to infections and develop into long-lived memory cells. This work is crucial for understanding how the immune system remembers pathogens and provides protection upon subsequent exposures, which is the fundamental principle behind vaccination. The Goldrath Lab aims to identify the transcriptional and signaling events that control memory T cell numbers and their functional capacity. Vaccines have been among the most effective medical interventions, exemplified by the eradication of smallpox and the near elimination of polio. However, many diseases remain challenging for conventional vaccine strategies, and the immune system's potential to combat tumors is an emerging area of interest. Ultimately, Professor Goldrath's research seeks to develop new methods to harness the immune system to protect against infections and eradicate malignancies.

Research topics

• Biology
• Genetics
• Immunology
• Medicine
• Cell biology
• Literature
• Pathology
• Art
• Environmental ethics
• Neuroscience

Selected publications

• CD8+ T cell metabolism in infection and cancer

  Nature reviews. Immunology · 2021 · 594 citations

  Senior authorCorresponding
  DOI

• The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

  Nature Communications · 2021 · 329 citations

  Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-cell RNA sequencing to neutrophils from normal and inflamed mouse tissues. Whereas conventional clustering yields multiple alternative organizational structures, diffusion mapping plus RNA velocity discloses a single developmental spectrum, ordered chronologically. Termed here neutrotime, this spectrum extends fro…

  DOI

• Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

  Immunity · 2020 · 286 citations

  Senior authorCorresponding
  DOI

• Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

  Science Immunology · 2020 · 274 citations

  cells in IBD.

  DOI

• Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

  Proceedings of the National Academy of Sciences · 2020 · 118 citations

  Senior authorCorresponding

  Memory CD8 T cells provide durable protection against diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-resident populations. Paradigmatic studies have demonstrated that circulating memory cells can be further divided into effector memory (Tem) and central memory (Tcm) populations based on discrete functional characteristics. Following resolution of infection, we identified a persisting antigen-specific CD8 T cell population that was terminally fa…

  PublisherOA PDFDOI

Recent grants

• Regulation of T cell immunity to viral infection

  NIH · $5.4M · 2007–2024

• Project 3 - Zuniga

  NIH · $19.6M · 2018–2024

• T cell maintenance: molecular mediators of T cell differentiation and survival

  NIH · $6.1M · 2006–2022

Frequent coauthors

• Mark P. Rubinstein

  60 shared

• Christophe Benoist

  Harvard University

  55 shared

• Diane Mathis

  Harvard University

  49 shared

• Andrew L. Doedens

  45 shared

• Kutlu G. Elpek

  Sana Biotechnology (United States)

  29 shared

• J. Justin Milner

  University of North Carolina at Chapel Hill

  28 shared

• John T. Chang

  VA San Diego Healthcare System

  28 shared

• Shannon J. Turley

  28 shared

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