Brigid Boland
· MDUniversity of California, San Diego · Gastroenterology
Active 1983–2026
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About
Brigid Boland is an Associate Adjunct Professor in the Department of Medicine at UC San Diego. She completed her MD at UC San Francisco School of Medicine in 2008, following her undergraduate studies at Yale University in 2003. Her education and training include an Advanced Fellowship at UC San Diego in 2015, a Fellowship at UC San Diego in 2013, and a Residency at UC San Diego in 2010. Her research focuses on gene expression, inflammatory bowel disease, personalized medicine, biomarkers, ulcerative colitis, and Crohn's disease. She is involved in clinical trials and research activities aimed at elucidating molecular determinants and predictors of inflammatory bowel diseases, utilizing single-cell RNA and protein approaches. Her work includes identifying biomarkers predictive of clinical and endoscopic responses to therapies such as vedolizumab, and she has contributed to the understanding of molecular disease subtypes in Crohn's disease and ulcerative colitis. Boland has received awards including the UCSD Career Development Award, KL2 CCFA Career Development Award, and recognition as a Future Leader by CCFA San Diego/Riverside.
Research topics
- Medicine
- Immunology
- Internal medicine
- Biology
- Biochemistry
- Computational biology
- Genetics
- Chemistry
- Bioinformatics
- Gastroenterology
Selected publications
Global chemical effects of the microbiome include new bile-acid conjugations
Nature · 2020 · 581 citations
Science Immunology · 2020 · 274 citations
1st authorCorrespondingcells in IBD.
Reverse metabolomics for the discovery of chemical structures from humans
Nature · 2023 · 163 citations
. Culture of bacteria belonging to the Bifidobacterium, Clostridium and Enterococcus genera produced these bile amidates. Because searching repositories with tandem mass spectrometry spectra has only recently become possible, this reverse metabolomics approach can now be used as a general strategy to discover other molecules from human and animal ecosystems.
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population
Proceedings of the National Academy of Sciences · 2020 · 118 citations
Memory CD8 T cells provide durable protection against diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-resident populations. Paradigmatic studies have demonstrated that circulating memory cells can be further divided into effector memory (Tem) and central memory (Tcm) populations based on discrete functional characteristics. Following resolution of infection, we identified a persisting antigen-specific CD8 T cell population that was terminally fa…
Risankizumab for Ulcerative Colitis
JAMA · 2024 · 102 citations
Importance: The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit of IL-23) for the treatment of ulcerative colitis are unknown. Objective: To evaluate the efficacy and safety of risankizumab when administered as an induction and a maintenance therapy for patients with ulcerative colitis. Design, Setting, and Participants: Two phase 3 randomized clinical trials were conducted. The induction trial was conducted at 261 clinical centers (in 41 countrie…
Recent grants
Frequent coauthors
- 154 shared
William J. Sandborn
- 143 shared
Siddharth Singh
- 137 shared
Parambir S. Dulai
Northwestern University
- 66 shared
Niels Vande Casteele
University of California, San Diego
- 64 shared
John T. Chang
VA San Diego Healthcare System
- 63 shared
Eugenia Shmidt
University of Minnesota
- 55 shared
Matthew Bohm
Indiana University School of Medicine
- 54 shared
Arun Swaminath
Education
- 2008
MD
UCSF Medical Center
Awards & honors
- UCSD 2017 - 2019 KL2 CCFA (2017 - 2019)
- Career Development Award AGA (2015 - 2018)
- Future Leader CCFA San Diego/Riverside (2017)
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