Henk Granzier

About

Henk Granzier is a Professor in the Department of Cellular and Molecular Medicine at the University of Arizona. His professional profile is listed under the Biochemistry and Molecular & Cellular Biology Graduate Program. The page does not provide specific details about his research focus, background, or key contributions.

Research topics

• Medicine
• Biology
• Cell biology
• Internal medicine
• Endocrinology
• Cardiology
• Computer Science
• Biochemistry
• Genetics
• Molecular biology

Selected publications

• Research Priorities for Heart Failure With Preserved Ejection Fraction

  Circulation · 2020 · 401 citations

  Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is rising in prevalence, is associated with high morbidity and mortality and is considered to be the greatest unmet need in cardiovascular medicine today because of a general lack of effective treatments. To address this challenging syndrome, the National Heart, Lung, and Blood Institute convened a working group made up of experts in HFpEF and novel research methodologies to discuss research gaps and to pr…

  DOI

• Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

  eLife · 2020 · 125 citations

  Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochondrial ROS in cardiomyocytes from old mice, accompanied by reduced protein oxidation and a shift towards a more reduced protein thiol redox state in old hearts. Improved diastolic function was concorda…

  DOI

• MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling

  Cardiovascular Research · 2020 · 100 citations

  AIMS: Heart failure is a major complication in cancer treatment due to the cardiotoxic effects of anticancer drugs, especially from the anthracyclines such as doxorubicin (DXR). DXR enhances oxidative stress and stimulates matrix metalloproteinase-2 (MMP-2) in cardiomyocytes. We investigated whether MMP inhibitors protect against DXR cardiotoxicity given the role of MMP-2 in proteolyzing sarcomeric proteins in the heart and remodelling the extracellular matrix. METHODS AND RESULTS: Eight-week-ol…

  DOI

• Differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in cardiomyocytes from obese diabetic heart failure with preserved ejection fraction model

  Cardiovascular Research · 2024-04-26 · 33 citations

  articleOpen access

  AIMS: Sex differences in heart failure with preserved ejection fraction (HFpEF) are important, but key mechanisms involved are incompletely understood. While animal models can inform about sex-dependent cellular and molecular changes, many previous pre-clinical HFpEF models have failed to recapitulate sex-dependent characteristics of human HFpEF. We tested for sex differences in HFpEF using a two-hit mouse model (leptin receptor-deficient db/db mice plus aldosterone infusion for 4 weeks; db/db +…

  PublisherOA PDFDOI

• Discovery of Titin and Its Role in Heart Function and Disease

  Circulation Research · 2025-01-02 · 29 citations

  review1st authorCorresponding

  This review examines the giant elastic protein titin and its critical roles in heart function, both in health and disease, as discovered since its identification nearly 50 years ago. Encoded by the TTN (titin gene), titin has emerged as a major disease locus for cardiac disorders. Functionally, titin acts as a third myofilament type, connecting sarcomeric Z-disks and M-bands, and regulating myocardial passive stiffness and stretch sensing. Its I-band segment, which includes the N2B element and t…

  PublisherDOI

Recent grants

• Function of Giant Sarcomere Matrix Proteins in Muscle

  NIH · $6.6M · 1995–2021

• NIH Grant R01HL067274

  NIH · $1.0M · 2006

• NIH Grant R01AR060697

  NIH · $1.7M · 2017

Frequent coauthors

• Siegfried Labeit

  350 shared

• Carlos Hidalgo

  University of Arizona

  294 shared

• Coen A. C. Ottenheijm

  Amsterdam University Medical Centers

  236 shared

• Alan H. Beggs

  229 shared

• Michael W. Lawlor

  214 shared

• Lindsay C. Swanson

  Boston Children's Hospital

  205 shared

• Jocelyn Laporte

  Inserm

  198 shared

• Elizabeth T. DeChene

  Children's Hospital of Philadelphia

  198 shared

Similar researchers at University of Arizona

• Hongmin Lih-75
• Guang Yaoh-45
• Felicia Goodrumh-39