Felicia Goodrum

About

Felicia Goodrum is an Interim Associate Department Head in Immunobiology at the University of Arizona. She is associated with the Biochemistry and Molecular & Cellular Biology Graduate Program. Her professional profile is available through the university's website. The page acknowledges her role within the department and her connection to the university, but does not provide specific details about her research focus, background, or key contributions.

Research topics

• Virology
• Immunology
• Political Science
• Pathology
• Medicine
• Biology

Selected publications

• Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells

  Science Immunology · 2021-04-02 · 63 citations

  articleOpen access

  Plasmacytoid dendritic cells (pDCs) can rapidly produce interferons and other soluble factors in response to extracellular viruses or virus mimics such as CpG-containing DNA. pDCs can also recognize live cells infected with certain RNA viruses, but the relevance and functional consequences of such recognition remain unclear. We studied the response of primary DCs to the prototypical persistent DNA virus, human cytomegalovirus (CMV). Human pDCs produced high amounts of type I interferon (IFN-I) w…

  PublisherOA PDFDOI

• FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation

  Proceedings of the National Academy of Sciences · 2020-07-21 · 42 citations

  articleOpen access

  Significance Human cytomegalovirus (HCMV) infection is lifelong and persistent. Periodic reactivation of cytomegalovirus poses serious disease risk for immune-compromised patients. A critical driver of reactivation is expression of viral genes from the major immediate early locus. Recent paradigm-shifting evidence shows that reactivation is driven from promoters distinct from those that drive replication in permissive cells. Understanding the contextual control of these promoters and how they sp…

  PublisherOA PDFDOI

• The complex biology of human cytomegalovirus latency

  Advances in virus research · 2022-01-01 · 40 citations

  review1st authorCorresponding
  PublisherDOI

• Virology under the Microscope—a Call for Rational Discourse

  Journal of Virology · 2023 · 20 citations

  1st authorCorresponding

  Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of indiv…

  PublisherDOI

• Virology under the Microscope—a Call for Rational Discourse

  mSphere · 2023 · 9 citations

  1st authorCorresponding

  Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of indiv…

  PublisherDOI

Recent grants

• Molecular Switch Regulating Human Cytomegalovirus Replicative and Latent States

  NIH · $2.7M · 2018–2024

• Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic Cells

  NIH · $2.9M · 2025–2029

• CMV Control of Host Membrane Trafficking

  NIH · $2.1M · 2018–2024

Frequent coauthors

• Thomas Shenk

  Princeton University

  34 shared

• Kevin P. High

  Cincinnati Children's Hospital Medical Center

  27 shared

• Craig T. Jordan

  26 shared

• Jason Buehler

  21 shared

• Jeremy P. Kamil

  Louisiana State University Health Sciences Center Shreveport

  20 shared

• Michael Rak

  University of Arizona

  19 shared

• Donna Collins-McMillen

  University of Arizona

  18 shared

• Nathaniel J. Moorman

  University of North Carolina at Chapel Hill

  17 shared

Similar researchers at University of Arizona

• Henk Granzierh-91
• Hongmin Lih-75
• Guang Yaoh-45