Gregory E. Crawford

About

Gregory E. Crawford is the Wilburt C. Davison Distinguished Professor of Pediatrics and a Professor in Pediatrics at Duke University School of Medicine. He also holds the position of Associate Professor in Molecular Genetics and Microbiology and is an affiliate of the Duke Regeneration Center. His contact information includes an email at greg.crawford@duke.edu and his office is located in Room 2111 CIEMAS, Durham, NC. The page indicates his involvement in the Third Year University Program in Genetics and Genomics, highlighting his focus on genetics and genomics within the context of pediatrics and molecular biology.

Research topics

• Biology
• Genetics
• Psychiatry
• Psychology
• Medicine
• Neuroscience
• Clinical psychology
• Computational biology
• Computer Science
• Demography

Selected publications

• Mapping genomic loci implicates genes and synaptic biology in schizophrenia

  Nature · 2022 · 2693 citations

  , much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 pro…

  DOI

• Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

  Biological Psychiatry · 2021 · 240 citations

  DOI

• Targeted long-read sequencing identifies missing disease-causing variation

  The American Journal of Human Genetics · 2021 · 238 citations

  PublisherOA PDFDOI

• Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

  Molecular Psychiatry · 2020 · 219 citations

  ). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.

  DOI

• A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

  Biological Psychiatry · 2021 · 202 citations

  BACKGROUND: Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies. PGS methods differ in which DNA variants are included and the weights assigned to them; some require an independent tuning sample to help inform these choices. PGSs are evaluated in independent target cohorts with known disease status. Variability between target cohorts is observed in applications to rea…

  DOI

Recent grants

• NIH Grant R41GM119914

  NIH · $225k · 2017

• NIH Grant R21NS084336

  NIH · $422k · 2015

• NIH Grant R01ES023195

  NIH · $2.2M · 2018

Frequent coauthors

• Lingyun Song

  212 shared

• Alexias Safi

  Duke Medical Center

  134 shared

• Thomas G. Schulze

  National Institute of Mental Health

  94 shared

• Timothy E. Reddy

  Duke University

  92 shared

• Fabian Streit

  Central Institute of Mental Health

  71 shared

• Terrence S. Furey

  University of North Carolina at Chapel Hill

  66 shared

• Stephan Ripke

  Charité - Universitätsmedizin Berlin

  66 shared

• Josef Frank

  Heidelberg University

  62 shared

Similar researchers at Duke University

• Carolyn Coyneh-78
• Jen-Tsan Ashley Chih-73
• Cagla Erogluh-65