Cagla Eroglu

About

Cagla Eroglu is a Duke University faculty member holding the positions of Duke Health Distinguished Professor of Cell Biology, Professor of Cell Biology, and Vice Chair of Research. She is also a Professor in Neurobiology and a Faculty Network Member of the Duke Institute for Brain Sciences. Additionally, she is an Associate of the Duke Initiative for Science & Society and an Affiliate of the Duke Regeneration Center. Her research focuses on cell and molecular biology, with involvement in programs such as Developmental & Stem Cell Biology and the University Program in Genetics and Genomics. She is based at the 333A Nanaline Duke Building in Durham, North Carolina.

Research topics

• Biology
• Neuroscience
• Genetics
• Internal medicine
• Medicine
• Cell biology
• Physiology
• Psychology
• Biochemistry

Selected publications

• Chemico-genetic discovery of astrocytic control of inhibition in vivo

  Nature · 2020 · 245 citations

  DOI

• Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

  Neuron · 2020 · 196 citations

  PublisherOA PDFDOI

• Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

  Cell Reports · 2022 · 102 citations

  Gestational exposure to environmental toxins and socioeconomic stressors is epidemiologically linked to neurodevelopmental disorders with strong male bias, such as autism. We model these prenatal risk factors in mice by co-exposing pregnant dams to an environmental pollutant and limited-resource stress, which robustly activates the maternal immune system. Only male offspring display long-lasting behavioral abnormalities and alterations in the activity of brain networks encoding social interactio…

  DOI

• Astrocyte-secreted neurocan controls inhibitory synapse formation and function

  Neuron · 2024-04-03 · 73 citations

  articleOpen accessSenior authorCorresponding

  Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse development were identified; however, those that induce inhibitory synaptogenesis remain elusive. Here, we identify neurocan as an astrocyte-secreted inhibitory synaptogenic protein. After secretion from astrocytes, neurocan is cleaved into N- and C-terminal fragments. We found that these fragments have distinct localizations i…

  PublisherOA PDFDOI

• Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival

  Cell Reports · 2020 · 51 citations

  Senior authorCorresponding

  Huntington's disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration of the striatal projection neurons (SPNs) of the striatum. HD is widely accepted to be caused by a toxic gain-of-function of mutant HTT. However, whether loss of HTT function, because of dominant-negative effects of the mutant protein, plays a role in HD and whether…

  DOI

Recent grants

• Control of synapse formation and maturation by astrocytes

  NIH · $1.7M · 2012–2018

• Control of Astrocyte Development and Astrocyte-Synapse Interactions

  NIH · $1.9M · 2018–2023

• Environmental Toxins and Microglia-Synapse Interactions in Autism

  NIH · $2.1M · 2016–2021

Frequent coauthors

• Dhanesh Sivadasan Bindu

  Duke University Hospital

  104 shared

• Justin T Savage

  Duke University Hospital

  92 shared

• Francesco Paolo Ulloa Severino

  Duke University

  90 shared

• Kristina Sakers

  Duke University

  76 shared

• Scott H. Soderling

  Duke University

  73 shared

• J.J. Ramirez

  Duke University

  70 shared

• Christabel Xin Tan

  Duke University Hospital

  67 shared

• W. Christopher Risher

  Marshall University

  66 shared

Education

• Postdoctoral Research, Neurobiology

  Stanford University

  2008

• Ph.D., Biology

  Ruprecht Karls Universitat Heidelberg

  2002

• Predoctoral Student, Structural Biology

  European Molecular Biology Laboratory

  2002

• M.Sc., Molecular Biology and Genetics

  Bilkent Universitesi

  1998

• B.Sc., Chemical Engineering

  Orta Dogu Teknik Universitesi

  1996

Similar researchers at Duke University

• Gregory E. Crawfordh-92
• Carolyn Coyneh-78
• Jen-Tsan Ashley Chih-73