Jen-Tsan Ashley Chi

About

Jen-Tsan Ashley Chi is a professor at Duke University School of Medicine with appointments in multiple departments including Molecular Genetics and Microbiology, Medicine, Cell Biology, Pharmacology and Cancer Biology, Radiation Oncology, and Integrative Immunobiology. He is also a member of the Duke Cancer Institute. His research focuses on molecular genetics, cancer biology, and immunobiology, contributing to the understanding of disease mechanisms and potential therapeutic approaches. Dr. Chi is involved in various educational programs, including the Program in Cell and Molecular Biology and the Third Year University Program in Genetics and Genomics, indicating a strong commitment to training the next generation of scientists and clinicians.

Research topics

• Cell biology
• Biology
• Cancer research
• Biochemistry
• Chemistry
• Genetics

Selected publications

• A guideline on the molecular ecosystem regulating ferroptosis

  Nature Cell Biology · 2024-02-29 · 238 citations

  reviewOpen access
  PublisherOA PDFDOI

• MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis

  Nature Metabolism · 2020 · 175 citations

  Senior authorCorresponding
  DOI

• International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

  Autophagy · 2024-03-06 · 167 citations

  reviewOpen access

  : 3-MA:3-methyladenine; 4HNE: 4-hydroxynonenal; ACD: accidentalcell death; ADF: autophagy-dependentferroptosis; ARE: antioxidant response element; BH2:dihydrobiopterin; BH4: tetrahydrobiopterin; BMDMs: bonemarrow-derived macrophages; CMA: chaperone-mediated autophagy; CQ:chloroquine; DAMPs: danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR: electronparamagnetic resonance; ER, endoplasmic reticulum; FRET: Försterresonance energy transfer; GFP: green fluoresce…

  PublisherOA PDFDOI

• Zinc transporter ZIP7 is a novel determinant of ferroptosis

  Cell Death and Disease · 2021 · 127 citations

  Senior authorCorresponding

  Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages. The name of ferroptosis indicates that the ferroptotic death process depends on iron, but not other metals, as one of its canonical features. Here, we reported that zinc is also essential for ferroptosis in breast and renal cancer cells. Zinc chelator suppressed ferroptosis, and zinc addition promoted ferroptosis, even during iron c…

  DOI

• The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2

  Molecular Cancer Research · 2021 · 101 citations

  Senior authorCorresponding

  Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-reactive oxygen species. A growing number of studies indicate ferroptosis as an important tumor suppressor mechanism having therapeutic potential in cancers. Previously, we identified TAZ, a Hippo pathway effector, regulates ferroptosis in renal and ovarian cancer cells. Because YAP (Yes-associated protein 1) is the one and only paralog of TAZ, sharing high sequence similarity and functional redundancy wit…

  DOI

Recent grants

• Biochemical and functional investigation of the novel enzymatic activities of MESH1

  NIH · $2.0M · 2018–2024

• The regulation dephosphorylated-CoA-capped RNA and innate immunity by MESH1

  NIH · $199k · 2020–2022

• Metabolic regulation of KLHL proteins through O-glycosylation

  NIH · $541k · 2019–2023

Frequent coauthors

• Stephen J. Freedland

  Durham VA Medical Center

  81 shared

• Po‐Han Chen

  Yale University

  76 shared

• Chao‐Chieh Lin

  70 shared

• Jianli Wu

  Duke University

  57 shared

• Mark W. Dewhirst

  50 shared

• Patrick O. Brown

  Stanford University

  45 shared

• Everardo Macias

  Duke Medical Center

  39 shared

• Chien‐Kuang Cornelia Ding

  39 shared

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