Carolyn Coyne

About

Carolyn Coyne is the George Barth Geller Distinguished Professor of Immunology at Duke University School of Medicine. She holds multiple professorships including Professor of Integrative Immunobiology, Pathology, Cell Biology, and Molecular Genetics and Microbiology. She is a member of the Duke Human Vaccine Institute and the Duke Cancer Institute. Her research focuses on immunology, cell and molecular biology, and genetics, contributing to the understanding of immune responses and vaccine development. She is actively involved in the Program in Cell and Molecular Biology and the University Program in Genetics and Genomics.

Research topics

• Political Science
• Virology
• Biology
• Medicine
• Pathology
• Immunology
• Law
• Genetics
• Cell biology
• Pediatrics

Selected publications

• Infections at the maternal–fetal interface: an overview of pathogenesis and defence

  Nature Reviews Microbiology · 2021 · 429 citations

  Senior authorCorresponding
  DOI

• Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

  eLife · 2022 · 127 citations

  Senior authorCorresponding

  Infections at the maternal-fetal interface can directly harm the fetus and induce complications that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived placental trophoblasts and the maternal decidua must provide antimicrobial defenses at this critical interface without compromising its integrity. Here, we developed matched trophoblast (TO) and decidua organoids (DO) from human placentas to define the relative contributions of these cells to antiviral defenses at…

  DOI

• A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop

  American Journal of Obstetrics and Gynecology · 2021 · 72 citations

  DOI

• Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing

  eLife · 2024-11-01 · 21 citations

  articleOpen accessSenior author

  The syncytiotrophoblast (STB) is a multinucleated cell layer that forms the outer surface of human chorionic villi. Its unusual structure, with billions of nuclei in a single cell, makes it difficult to resolve using conventional single-cell methods. To better understand STB differentiation, we performed single-nucleus and single-cell RNA sequencing on placental tissue and trophoblast organoids (TOs). Single-nucleus RNA-seq was essential for capturing STB populations, revealing three nuclear sub…

  PublisherOA PDFDOI

• Innate immune responses to pathogens at the maternal–fetal interface

  Nature reviews. Immunology · 2025-06-18 · 14 citations

  review
  PublisherDOI

Recent grants

• Innate immune signaling in placental antiviral defenses

  NIH · $3.5M · 2019–2025

• Placental resistance and response to the teratogenic pathogen Toxoplasma gondii

  NIH · $2.8M · 2022–2027

• The Role of FcRn in Echovirus Entry and Pathogenesis

  NIH · $2.4M · 2020–2026

Frequent coauthors

• Yoel Sadovsky

  100 shared

• Alexandra I. Wells

  The University of Texas Southwestern Medical Center

  59 shared

• Nitin Arora

  University of Alabama at Birmingham

  50 shared

• Azia S. Evans

  50 shared

• Jean‐François Mouillet

  Magee-Womens Research Institute

  46 shared

• Nicholas J. Lennemann

  University of Alabama at Birmingham

  40 shared

• Stefanie A. Morosky

  39 shared

• Liheng Yang

  Duke University

  39 shared

Similar researchers at Duke University

• Gregory E. Crawfordh-92
• Jen-Tsan Ashley Chih-73
• Cagla Erogluh-65