Gilad Barnea

About

Gilad Barnea, Ph.D., is a professor involved in research utilizing molecular genetic tools to study genes, circuits, and behavior. He is a member of the Barnea Lab, which focuses on understanding the genetic and neural mechanisms underlying behavior through advanced genetic and neurobiological techniques. His work contributes to elucidating the complex interactions between genes and neural circuits that influence behavior, although specific details of his research focus are not provided in the page text.

Research topics

• Biology
• Neuroscience
• Genetics
• Medicine
• Cell biology
• Psychology
• Botany

Selected publications

• Circuits that encode and guide alcohol-associated preference

  eLife · 2020 · 50 citations

  . During memory expression, subsets of dopamine neurons directly and indirectly modulate the activity of interconnected glutamatergic and cholinergic mushroom body output neurons (MBON). Transsynaptic tracing of neurons important for memory expression revealed a convergent center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in integration of naïve and learned responses. These findings provide a circuit framework through wh…

  PublisherDOI

• Complex representation of taste quality by second-order gustatory neurons in Drosophila

  Current Biology · 2022-08-15 · 42 citations

  articleOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

• retro-Tango enables versatile retrograde circuit tracing in Drosophila

  eLife · 2023-05-11 · 35 citations

  articleOpen accessSenior author

  Transsynaptic tracing methods are crucial tools in studying neural circuits. Although a couple of anterograde tracing methods and a targeted retrograde tool have been developed in Drosophila melanogaster , there is still need for an unbiased, user-friendly, and flexible retrograde tracing system. Here, we describe retro -Tango, a method for transsynaptic, retrograde circuit tracing and manipulation in Drosophila . In this genetically encoded system, a ligand-receptor interaction at the synapse t…

  PublisherDOI

• Coordination of two enhancers drives expression of olfactory trace amine-associated receptors

  Nature Communications · 2021-06-18 · 27 citations

  articleOpen access

  Olfactory sensory neurons (OSNs) are functionally defined by their expression of a unique odorant receptor (OR). Mechanisms underlying singular OR expression are well studied, and involve a massive cross-chromosomal enhancer interaction network. Trace amine-associated receptors (TAARs) form a distinct family of olfactory receptors, and here we find that mechanisms regulating Taar gene choice display many unique features. The epigenetic signature of Taar genes in TAAR OSNs is different from that…

  PublisherOA PDFDOI

• Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

  eLife · 2023-12-18 · 23 citations

  articleOpen access

  Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in the mouse genome in a probabilistic, yet stereotypic fashion. Here, we propose that topographic restrictions in OR expression are established in neuronal progenitors by two opposing forces: polygenic transcription and genomic silencing, both of which are influenced by dorsoventral gradients of transcription factors NFIA, B, and X. Poly…

  PublisherDOI

Recent grants

• Functional mapping of mammalian neural circuits

  NIH · $1.3M · 2014–2018

• NIH Grant R01MH086920

  NIH · $1.5M · 2013

• NIH Grant R21DC014333

  NIH · $447k · 2017

Frequent coauthors

• Mustafa Talay

  105 shared

• Altar Sorkaç

  61 shared

• Nathaniel J. Snell

  36 shared

• Stavros Lomvardas

  Columbia University

  35 shared

• Doruk Savaş

  34 shared

• Alexander Fleischmann

  Providence College

  30 shared

• Benjamin Shykind

  30 shared

• Nell Klimpert

  Allen Institute for Brain Science

  30 shared

Labs

• Barnea LabPI

Similar researchers at Brown University

• Karen Furieh-148
• Rena Wingh-146
• Lawrence Priceh-132