Stavros Lomvardas
· Professor of Biochemistry and Molecular Biophysics and NeuroscienceColumbia University · Biochemistry and Molecular Biophysics
Active 1999–2026
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
About
Stavros Lomvardas, PhD, is a Professor of Biochemistry and Molecular Biophysics and Neuroscience at Columbia University Irving Medical Center. His research focuses on sensory physiology and the study of synapses and circuits. As a faculty member in the Department of Biochemistry and Molecular Biophysics, Professor Lomvardas contributes to advancing the understanding of the molecular and cellular mechanisms underlying sensory systems and neural connectivity. His work integrates aspects of neuroscience and biochemistry to explore how sensory information is processed and transmitted through neural circuits.
Research topics
- Biology
- Virology
- Genetics
- Cell biology
- Neuroscience
- Internal medicine
- Pathology
- Medicine
- Immunology
- Geography
Selected publications
Cell · 2022 · 267 citations
Senior authorCorrespondingRNA-mediated symmetry breaking enables singular olfactory receptor choice
Nature · 2023-12-20 · 65 citations
articleOpen accessSenior authorCorrespondingAbstract Olfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one of approximately 2,000 or more OR alleles 1,2 . OR gene choice is mediated by a multichromosomal enhancer hub that activates transcription at a single OR 3,4 , followed by OR-translation-dependent feedback that stabilizes this choice 5,6 . Here, using single-cell genomics, we show formation of many competing hubs with variab…
ER stress transforms random olfactory receptor choice into axon targeting precision
Cell · 2022 · 56 citations
Senior authorCorrespondingDisruption of nuclear architecture as a cause of COVID-19 induced anosmia
bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 26 citations
Senior authorCorrespondingAbstract Olfaction relies on a coordinated partnership between odorant flow and neuronal communication. Disruption in our ability to detect odors, or anosmia, has emerged as a hallmark symptom of infection with SARS-CoV-2, yet the mechanism behind this abrupt sensory deficit remains elusive. Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory rece…
eLife · 2023-12-18 · 23 citations
articleOpen accessSenior authorOlfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in the mouse genome in a probabilistic, yet stereotypic fashion. Here, we propose that topographic restrictions in OR expression are established in neuronal progenitors by two opposing forces: polygenic transcription and genomic silencing, both of which are influenced by dorsoventral gradients of transcription factors NFIA, B, and X. Poly…
Recent grants
Converting stochastic olfactory receptor expression to stereotypic axon guidance programs
NIH · $5.0M · 2016–2026
NIH · $1.2M · 2014
NIH · $2.3M · 2014
Frequent coauthors
- 38 shared
Kevin D. Monahan
Rutgers, The State University of New Jersey
- 35 shared
Gilad Barnea
- 27 shared
Elizaveta Bashkirova
Columbia University
- 24 shared
Ira Schieren
Brain (Germany)
- 21 shared
Alexander Fleischmann
Providence College
- 21 shared
Nell Klimpert
Allen Institute for Brain Science
- 19 shared
Ariel Pourmorady
Columbia University
- 17 shared
Benjamin Shykind
Labs
Awards & honors
- Harold M. Weintraub Award for outstanding achievement during…
- Samuel W. Rover and Lewis Rover Awards for outstanding achie…
- Helen Hay Whitney Foundation Fellowship (2003-2006)
- NIH Director's New Innovator Award (2009-2014)
- Rett Syndrome Research Trust, New Investigator Award (2009-2…
Similar researchers at Columbia University
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Stavros Lomvardas
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup