Gary W. Falk

About

Gary W. Falk, MD, MS, is an Emeritus Professor of Medicine (Gastroenterology) at the University of Pennsylvania's Perelman School of Medicine. He is a member of the Hospital of the University of Pennsylvania Abramson Comprehensive Cancer Center Cancer Control Research Program and holds the position of University Associate Staff at Children's Hospital of Philadelphia. Dr. Falk specializes in esophageal diseases, including Barrett's esophagus, eosinophilic esophagitis, GERD diagnosis and treatment, achalasia, motility abnormalities, extraesophageal GERD, dysphagia, and esophageal cancer. His research focuses on the chemoprevention, detection, diagnosis, and epidemiology of Barrett's esophagus and eosinophilic esophagitis, as well as advanced endoscopic imaging techniques. Dr. Falk's educational background includes a B.S. in Biology-Geology from the University of Rochester, an M.D. from the University of Rochester School of Medicine and Dentistry, and an M.S. in Clinical Research from Case Western Reserve University School of Medicine Clinical Scholars Program.

Research topics

• Medicine
• Internal medicine
• Pathology
• Biology
• Computer Science
• Gastroenterology
• Intensive care medicine
• Surgery
• Artificial Intelligence
• Cancer research

Selected publications

• Diagnosis and Management of Barrett's Esophagus: An Updated ACG Guideline

  The American Journal of Gastroenterology · 2022-03-31 · 476 citations

  articleOpen access

  Barrett's esophagus (BE) is a common condition associated with chronic gastroesophageal reflux disease. BE is the only known precursor to esophageal adenocarcinoma, a highly lethal cancer with an increasing incidence over the last 5 decades. These revised guidelines implement Grading of Recommendations, Assessment, Development, and Evaluation methodology to propose recommendations for the definition and diagnosis of BE, screening for BE and esophageal adenocarcinoma, surveillance of patients wit…

  PublisherOA PDFDOI

• Eosinophilic Esophagitis

  JAMA · 2021 · 265 citations

  Senior authorCorresponding

  Importance: Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease of the esophagus that affects an estimated 34.4/100 000 people in Europe and North America. EoE affects both children and adults, and causes dysphagia, food impaction of the esophagus, and esophageal strictures. Observations: EoE is defined by symptoms of esophageal dysfunction, such as vomiting, dysphagia, or feeding difficulties, in a patient with an esophageal biopsy demonstrating at least 15 eosinoph…

  DOI

• Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

  New England Journal of Medicine · 2020-10-21 · 263 citations

  articleOpen access

  BACKGROUND: Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, and a lack of adequate treatments. Mast-cell activity may contribute to the pathogenesis of the conditions. AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils and inhibits mast cells and that has shown potential in animal models as a treatment for eosinophilic gastritis and duodenitis. METHODS: In this phase 2 trial, we…

  PublisherOA PDFDOI

• International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

  Clinical Gastroenterology and Hepatology · 2022 · 165 citations

  DOI

• Generation and Characterization of Patient‐Derived Head and Neck, Oral, and Esophageal Cancer Organoids

  Current Protocols in Stem Cell Biology · 2020 · 90 citations

  ) Support Protocol: Production of RN in HEK293T cell conditioned medium.

  DOI

Frequent coauthors

• Amitabh Chak

  249 shared

• William M. Grady

  243 shared

• Jacques Van Dam

  210 shared

• John M. Inadomi

  University of Utah

  209 shared

• Nicholas J. Shaheen

  207 shared

• Sanford D. Markowitz

  202 shared

• Prateek Sharma

  Vellore Institute of Technology University

  202 shared

• Sumeet K. Mittal

  196 shared

Labs

• Falk LabPI

Education

• MS, Clinical Scholars

  Case Western Reserve University

  2006

• MD, Medicine

  University of Rochester

  1980

• BS, Biology-Geology

  University of Rochester

  1976

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• Craig B. Thompsonh-277
• Daniel J Raderh-236