Ethan M. Goldberg
University of Pennsylvania · Rehabilitation Medicine
Active 1969–2024
About
Ethan M. Goldberg, M.D., Ph.D., is an Associate Professor of Neurology at the Perelman School of Medicine at the University of Pennsylvania and a member of the Computational Neuroscience Initiative. He serves as the Director of The Epilepsy Neurogenetics Initiative (ENGIN) at The Children's Hospital of Philadelphia. His clinical expertise includes pediatric neurology, epilepsy, neurogenetics, developmental delay, autism spectrum disorder, and related neurological conditions. His research focuses on epilepsy, neurobiology of disease, physiology, ion channels, and two-photon imaging. Goldberg's educational background includes a B.A. in Neurobiology from Harvard University, a Ph.D. in Physiology & Neuroscience from New York University School of Medicine, and an M.D. from the same institution. He has also obtained certifications in Research Mentor Training from the University of Wisconsin-Madison and in Raising a Resilient Scientist Series from the NIH Office of Intramural Training & Education. His work involves characterizing genetic disorders related to epilepsy, investigating the neurobiological mechanisms underlying epileptic conditions, and developing targeted treatments.
Research topics
- Psychiatry
- Engineering ethics
- Finance
- Biology
- Business
- Cell biology
- Medicine
- Nanotechnology
- Pathology
- Engineering
Selected publications
Epilepsia · 2022 · 137 citations
- Medicine
- Engineering ethics
- Psychiatry
The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility of precision treatments tailored to specific genetic etiologies. Despite this, current medical therapy for most epilepsies remains imprecise, aimed primarily at empirical seizure reduction rather than targeting specific disease processes. Intellectual and technological leaps in diagnosis over the past 10 years have not yet translated to routine changes in clinical practice. However, the epilepsy community is poised to make impressive gains in precision therapy, with continued innovation in gene discovery, diagnostic ability, and bioinformatics; increased access to genetic testing and counseling; fuller understanding of natural histories; agility and rigor in preclinical research, including strategic use of emerging model systems; and engagement of an evolving group of stakeholders (including patient advocates, governmental resources, and clinicians and scientists in academia and industry). In each of these areas, we highlight notable examples of recent progress, new or persistent challenges, and future directions. The future of precision medicine for genetic epilepsy looks bright if key opportunities on the horizon can be pursued with strategic and coordinated effort.
Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation
Cell stem cell · 2020 · 484 citations
- Biology
- Cell biology
- Nanotechnology
Recent grants
NSF · $357k · 2017–2020
NIH · $921k · 2016–2022
Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndrome
NIH · $3.5M · 2019–2029
Frequent coauthors
- 69 shared
Ingo Helbig
University of Pennsylvania
- 29 shared
Ala Somarowthu
- 26 shared
Christel Depienne
University of Duisburg-Essen
- 24 shared
Katherine L. Helbig
Children's Hospital of Philadelphia
- 22 shared
Renzo Guerrini
University of Florence
- 22 shared
Boris Keren
Sorbonne Université
- 21 shared
Dennis Lal
- 21 shared
Stewart A. Anderson
Education
- 2013
Residency, Neurology
Hospital of the University of Pennsylvania
- 2013
Residency, Child Neurology
Children's Hospital of Philadelphia
- 2010
Residency, Pediatrics
Children's Hospital of Philadelphia
- 2008
M.D.
NYU Langone Medical Center
- 2006
Ph.D., Physiology & Neuroscience
NYU Langone Medical Center
- 1999
B.A., Neurobiology
Harvard University
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